Browsing by Author "Uvez, Ayca"
Now showing items 1-5 of 5
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Chloroquine used in combination with chemotherapy synergistically suppresses growth and angiogenesis in vitro and in vivo
Gurel-Gurevin, Ebru; Kiyan, Hulya Tuba; Esener, Osman Behzat Burak; Aydinlik, Seyma; Uvez, Ayca; Ulukaya, Engin; Dimas, Konstantinos; Armutak, Elif Ilkay (Int Inst Anticancer Research, 2018)Background: The inhibition of autophagy using pharmacological inhibitors such as chloroquine may be an effective strategy to overcome chemotherapy or resistance to anti-angiogenic therapy. Materials and Methods: The cytotoxic ... -
Effects of combined administration of doxorubicin and chloroquine on lung pathology in mice with solid Ehrlich ascites carcinoma
Utkusavas, Ayfer; Gurel Gurevin, Ebru; Yilmazer, Nadim; Uvez, Ayca; Oztay, Fusun; Bulut, Huri (2022)Combined use of a chemotherapeutic agent and an autophagy inhibitor is a novel cancer treatment strategy. We investigated the effects of chloroquine (CQ) on lung pathology caused by both solid Ehrlich ascites carcinoma ... -
Evidence for heterogeneity in response to treatment in mammary tumors of dogs as happens in humans
Turna, Ozge; Uvez, Ayca; Baykal, Aslihan; Develi, Elif Sedef; Diramali, Murat; Sonmez, Kivilcim; Karakas, Didem; Kasikci, Guven; Armutak, Elif Ilkay; Ulukaya, Engin (NCI CPTAC Assay Portal, 2022)Tumors are formed by various clones developed over a long time. This gives rise to a heterogeneous nature. This heterogeneity is the hardest challenge in the treatment of cancers because it is the main reason for drug ... -
Palladium (II) complex and thalidomide intercept angiogenic signaling via targeting FAK/Src and Erk/Akt/PLC gamma dependent autophagy pathways in human umbilical vein endothelial cells
Aydinlik, Seyma; Uvez, Ayca; Kiyan, Hulya Tuba; Gurel-Gurevin, Ebru; Yilmaz, Veysel Turan; Ulukaya, Engin (Elsevier, 2021)The current study assessed the effects of the thalidomide and palladium (II) saccharinate complex of terpyridine on the suppression of angiogenesis-mediated cell proliferation. The viability was assessed after treatment ... -
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
Cevatemre, Buse; Erkisa Genel, Merve; Aztopal, Nazlihan; Karakas Zeybek, Didem; Alper, Pinar; Tsimplouli, Chrisiida; Sereti, Evangelia; Dimas, Konstantinos; Armutak, Elif I. Ikitimur; Gurevin, Ebru Gurel; Uvez, Ayca; Mori, Mattia; Berardozzi, Simone; Ingallina, Cinzia; D'Acquarica, Ilaria; Botta, Bruno; Ozpolat, Bulent; Ulukaya, Engin (Academic Press Ltd- Elsevier Science Ltd, 2018)Several natural products have been suggested as effective agents for the treatment of cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy hypothesis, it is worth investigating the ...
