Browsing by Author "Uygun, Vedat"
Now showing items 1-15 of 15
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Different kinetics and risk factors for isolated extramedullary relapse after allogeneic hematopoietic stem cell transplantation in children with acute leukemia
Hazar, Volkan; Öztürk, Gülyüz; Yalçın, Koray; Uygun, Vedat; Aksoylar, Serap; Bozkurt, Ceyhun (Elsevier, 2021)Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the most frequent cause of posttransplant mortality. Isolated extramedullary relapse (iEMR) after HSCT is relatively rare ... -
Epstein‑Barr virus‑related lymphoproliferative disorders in T‑cell repleted haploidentical transplantation with post‑transplant cyclophosphamide
Uygun, Vedat; Ozsan, Nazan; Daloglu, Hayriye; Ozturkmen, Seda; Yalcin, Koray; Karasu, Gulsun; Yesilipek, Akif (Springer Link, 2021)EBV-associated lymphoproliferative disorders (LPDs) are common in hematopoietic stem cell transplantation (HSCT) with T-cell-depleted grafts, but are extremely rare in HSCT patients with T-cell-replete grafts with ... -
Hematopoetic stem cell transplantation in CD40 ligand deficiency
Uygun, Vedat; Uygun, Dilara Fatma Kocacik; Daloglu, Hayriye; Ozturkmen, Seda; Kilic, Suar Caki; Bingol, Aysen; Yalcin, Koray; Celen, Safiye Suna; Hazar, Volkan; Tezcan Karasu, Gulsun; Yesilipek, Akif (SPRINGERNATURE, 2020)[No Abstract] -
Hematopoietic stem cell transplantation in CD40 ligand deficiency: a single-center experience
Uygun, Dilara Fatma Kocacik; Uygun, Vedat; Tezcan Karasu, Gulsun; Daloglu, Hayriye; Ozturkmen, Seda Irmak; Celmeli, Fatih; Torun, Selda Hancerli; Ozen, Ahmet; Baris, Safa; Aydiner, Elif Karakoc; Yalcin, Koray; Kilic, Suar Caki; Hazar, Volkan; Bingol, Aysen; Yesilipek, Akif (Wiley, 2020)Deficiency of the CD40L, expressed on the surface of T lymphocytes, is caused by mutations in the glycoproteinCD40L (CD154)gene. Resulting defective humoral and cellular responses cause a clinical presentation that includes ... -
Hematopoietic stem cell transplantation in serine/threonine kinase 4 (stk4) deficiency: report of two cases and literature review
Uygun, Vedat; Keles, Sevgi; Daloglu, Hayriye; Ozturkmen, Seda; Yalcin, Koray; Karasu, Gulsun; Yesilipek, Akif (WILEY, 2022)Background Serine/threonine kinase 4 (STK4) deficiency is a combined immunodeficiency (CID) characterized by early onset recurrent bacterial, viral, and fungal infections. Allogeneic hematopoietic stem cell transplantation ... -
ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients
Eken, Ahmet; Cansever, Murat; Okus, Fatma Zehra; Erdem, Serife; Nain, Ercan; Azizoglu, Zehra Busra; Haliloglu, Yesim; Karakukcu, Musa; Ozcan, Alper; Devecioglu, Omer; Aksu, Guzide; Arikan Ayyildiz, Zeynep; Topal, Erdem; Karakoc Aydiner, Elif; Kiykim, Ayca; Metin, Ayse; Erol Cipe, Funda; Kaya, Aysenur; Artac, Hasibe; Reisli, Ismail; Guner, Sukru N.; Uygun, Vedat; Tezcan Karasu, Gulsun; Doenmez Altuntas, Hamiyet; Canatan, Halit; Oukka, Mohamed; Ozen, Ahmet; Chatila, Talal A.; Keles, Sevgi; Baris, Safa; Unal, Ekrem; Patiroglu, Turkan (Wiley, 2020)BackgroundDedicator of cytokinesis 8 (DOCK8) deficiency is the main cause of the autosomal recessive hyper-IgE syndrome (HIES). We previously reported the selective loss of group 3 innate lymphoid cell (ILC) number and ... -
Mutational landscape of severe combined immunodeficiency patients from Turkey
Fırtına, Sinem; Ng, Yuk Yin; Ng, Özden Hatırnaz; Kıykım, Ayça; Aydıner, Elif; Nepesov, Serdar; Camcıoğlu, Yıldız; Sayar, Esra H.; Reisli, İsmail; Torun, Selda H.; Çöğürlü, Tuba; Uygun, Dilara; Şimşek, Işıl E.; Kaya, Ayşenur; Erol Cipe, Funda; Çağdaş, Deniz; Yücel, Esra; Çekiç, Şükrü; Uygun, Vedat; Barış, Safa; Özen, Ahmet; Özbek, Ugur; Sayitoglu, Muge (Wiley, 2020)Severe combined immunodeficiency (SCID) has a diverse genetic aetiology, where a clinical phenotype, caused by single and/or multiple gene variants, can give rise to multiple presentations. The advent of next-generation ... -
Pearson syndrome in a child transplanted for diamond-blackfan anemia
Uygun, Vedat; Daloglu, Hayriye; Ozturkmen, Seda; Karasu, Gulsun; Yesilipek, Akif (Sociedad Argentina de Pediatria, 2021)Pearson syndrome (PS), shares a number of overlapping features with Diamond-Blackfan anemia (DBA), including early onset of severe anemia, making differential diagnosis important. Differential diagnosis of DBA and PS is ... -
Pearson syndrome in a patient transplanted for diamond-blackfan anemia
Tezcan Karasu, Gulsun; Uygun, Vedat; Daloglu, Hayriye; Ozturkmen, Seda; Yesilipek, Akif (SPRINGERNATURE, 2020)[No Abstract] -
Pre-transplantation vitamin D deficiency increases acute graft-versus-host disease after hematopoietic stem cell transplantation in thalassemia major patients
Daloğlu, Hayriye; Uygun, Vedat; Ozturkmen, Seda; Yalcın, Koray; Karasu, Gulsu; Yesilipek, Akif (WILEY, 2022)Background: Although there are many studies on the role of vitamin D deficiency (VDD) in hematopoetic stem cell transplantation (HSCT), outcomes have often reported conflicting results because of the heterogeneity of the ... -
Prognostic factors for survival in children who relapsed after allogeneic hematopoietic stem cell transplantation for acute leukemia
Hazar, Volkan; Tezcan Karasu, Gülsün; Öztürk, Gülyüz; Küpesiz, Alphan; Aksoylar, Serap; Özbek, Namık; Uygun, Vedat; İleri, Talia; Okur, Fatma Visal; Koçak, Ülker; Çakı Kılıç, Suar; Akçay, Arzu; Güler, Elif; Kansoy, Savaş; Karakükcü, Musa; Bayram, İbrahim; Aksu , Tekin; Yeşilipek, Akif; Karagün, Barbaros Şahin; Yılmaz, Şebnem; Ertem, Mehmet; Uçkan, Duygu; Fışgın, Tunç; Gürsel, Orhan; Yaman, Yöntem; Bozkurt, Ceyhun; Gökçe, Müge (2020)Background: Post-transplant relapse has a dismal prognosis in children with acute leukemia undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Data on risk factors, treatment options, and outcomes ... -
Ruxolitinib salvage therapy is effective for steroid-refractory graft-versus-host disease in children: a single-center experience
Uygun, Vedat; Tezcan Karasu, Gulsun; Daloglu, Hayriye; Ozturkmen, Seda; Kilic, Suar Caki; Yalcin, Koray; Celen, Safiye Suna; Hazar, Volkan; Yesilipek, Akif (Wiley, 2020)Background Despite the increasing performance of allogeneic hematopoietic cell transplantation over the last decades, graft-versus-host disease (GVHD) remains the main cause of morbidity and mortality. The efficacy of ... -
Thalassemia-free and graft-versus-host-free survival: outcomes of hematopoietic stem cell transplantation for thalassemia major, Turkish experience
We report the national data on the outcomes of hematopoietic stem cell transplantation (HSCT) for thalassemia major (TM) patients in Turkey on behalf of the Turkish Pediatric Stem Cell Transplantation Group. We retrospectively ... -
Timing of initiation of calcineurin inhibitors in pediatric haploidentical transplantation with post-transplantation cyclophosphamide: Effects on survival, relapse, and cytokine release syndrome
Uygun, Vedat; Karasu, Gülsüm; Yalçın, Koray; Öztürkmen, Seda; Daloğlu, Hayriye; Celen, Safiye Suna; Hazar, Volkan; Yeşilipek, Akif (Karger, 2022)Background: The use of unmanipulated haploidentical hematopoietic stem cell transplantations (haplo-HSCT) with post-transplant cyclophosphamide (PTCY) in children has emerged as an acceptable alternative to the patients ... -
Use of low cell dose for unmanipulated donor lymphocyte for management of cytomegalovirus infection: a single-center experience
Uygun, Vedat; Tezcan Karasu, Gulsun; Daloglu, Hayriye; Ozturkmen, Seda; Yalcın, Koray; Celen, Safiye Suna; Yesilipek, Akif (2020)Although advancements have been made in monitoring and preventing viral infections in HSCT patients, CMV reactivation still remains a critical post-transplant complication. Adoptive cell therapy is an alternative to ...
