Browsing by Author "Zarrabi, Ali"
Now showing items 1-20 of 56
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Advances in understanding the role of P-gp in doxorubicin resistance: molecular pathways, therapeutic strategies, and prospects
Mirzaei, Sepideh; Gholami, Mohammad Hossein; Hashemi, Farid; Zabolian, Amirhossein; Zarrabi, Ali (Elsevier, 2022)P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX) resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2, HIF-1α, miRNAs, and long noncoding (lnc)RNAs, ... -
AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation
Entezari, M.; Hashemi, D.; Taheriazam, A.; Zabolian, A.; Zabolian, A.; Fakhri, F.; Hashemi, M.; Hushmandi, K.; Ashrafizadeh, M.; Zarrabi, A.; Ertas, Y.N.; Mirzaei, S. (Elsevier, 2022)Diabetes mellitus (DM) is considered as a main challenge in both developing and developed countries, as lifestyle has changed and its management seems to be vital. Type I and type II diabetes are the main kinds and they ... -
Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic
Mostafavi, E.; Zarepour, A.; Barabadi, H.; Zarrabi, A.; Truong, L.B.; Medina-Cruz, D. (Elsevier B.V., 2022)The American Cancer Society estimated around 61,090 new cases of leukemia were diagnosed, and around 23,660 people died from this disease in the United States alone in 2021. Due to its burden on society, there is an unmet ... -
Cancer-Associated Fibroblasts Regulate the Plasticity of Breast Cancer Stemness through the Production of Leukemia Inhibitory Factor
Vaziri, N.; Shariati, L.; Zarrabi, Ali; Farazmand, A.; Javanmard, S.H. (Multidisciplinary Digital Publishing Institute (MDPI), 2021)Leukemia inhibitory factor (LIF), as a member of the interleukin-6 cytokine family, plays a complex role in solid tumors. However, the effect of LIF as a tumor microenvironment factor on plasticity control in breast cancer ... -
Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments
Varol, Aysegul; Sezen, Serap; Evcimen, Dilhan; Zarepour, Atefeh; Ulus, Gonul; Zarrabi, Ali; Badr, Gamal; Dastan, Sevgi Durna; Orbayoglu, Asya Gulistan (2022)Bee venom therapy is known as a traditional approach to curing many medical conditions such as arthritis, pain and rheumatism. Bee venom also provides promising potential for treating many cancers such as breast, lung, ... -
Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies
Paskeh, Mahshid Deldar Abad; Mirzaei, Sepideh; Gholami, Mohammad Hossein; Zarrabi, Ali; Zabolian, Amirhossein; Hashemi, Mehrdad; Hushmandi, Kiavash (Elsevier Science, 2021)Cervical cancer is the fourth common gynecologic cancer and is considered as second leading cause of death among women. Various strategies are applied in treatment of cervical cancer including radiotherapy, chemotherapy ... -
Characterization and optical properties of mechanochemically synthesized molybdenum-doped rutile nanoparticles and their electronic structure studies by density functional theory
Maleki-Ghaleh, H.; Shakeri, M.S.; Dargahi, Z.; Kavanlouei, M.; Kaveh Garabagh, H.; Moradpur-Tari, E.; Yourdkhani, A.; Fallah, A.; Zarrabi, A.; Koc, B.; Siadati, M.H. (Elsevier, 2022)The optical and electronic properties of molybdenum (Mo) doped rutile TiO2 prepared by the mechanochemical method were studied both experimentally and using density functional theory (DFT). The synthesized nanoparticles ... -
Chitosan: a versatile bio-platform for breast cancer theranostics
Madamsetty, Vijay Sagar; Tavakol, Shima; Moghassemi, Saeid; Dadashzadeh, Arezoo; Schneible, John D.; Fatemi, Iman; Zarrabi, Ali (ELSEVIER, 2022)Breast cancer is considered one of the utmost neoplastic diseases globally, with a high death rate of patients. Over the last decades, many approaches have been studied to early diagnose and treat it, such as chemotherapy, ... -
Citrus genus and its waste utilization: a review on health-promoting activities and industrial application
Khan, Usman Mir; Mir, Usman; Muhammad Aadil, Rana; Shahid, Muhammad; Sezen, Serap; Zarrabi, Ali; Ozdemir, Betul; Sevindik, Mustafa (2021)Citrus fruits such as oranges, grapefruits, lemons, limes, tangerines, and mandarins, whose production is increasing every year with the rise of consumer demand, are among the most popular fruits cultivated throughout the ... -
The convergence of in silico approach and nanomedicine for efficient cancer treatment; in vitro investigations on curcumin loaded multifunctional graphene oxide nanocomposite structure
Paknia, Fatemeh; Mohabatkar, Hassan; Ahmadi-Zeidabadi, Meysam; Zarrabi, Ali (Editions de Sante, 2022)The development of multifunctional nano-carriers with the ability of stimuli responsive controlled drug release can address many of the challenges of current cancer therapies. Graphene oxide (GO)-based nanomaterials with ... -
Correction: The long and short non-coding RNAs modulating EZH2 signaling in cancer (Journal of Hematology & Oncology, (2022), 15, 1, (18), 10.1186/s13045-022-01235-1)
Mirzaei, Sepideh; Gholami, Mohammad Hossein; Hushmandi, Kiavash; Hashemi, Farid; Zabolian, Amirhossein; Canadas, Israel; Zarrabi, Ali; Nabavi, Noushin; Aref, Amir Reza; Crea, Francesco; Wang, Yuzhuo; Ashrafizadeh, Milad; Kumar, Alan Prem (BioMed Central Ltd, 2022)The original article [1] contained an error in co-author, Farid Hashemi’s name which has since been corrected. © 2022, The Author(s). -
Curcumin and its derivatives in cancer therapy: potentiating antitumor activity of cisplatin and reducing side effects
Abadi, Asal Jalal; Mirzaei, Sepideh; Mahabady, Mahmood Khaksary; Hashemi, Farid; Zabolian, Amirhossein; Hashemi, Fardin; Raee, Pourya; Zarrabi, Ali (WILEY, 2021)Curcumin is a phytochemical isolated from Curcuma longa with potent tumor-suppressor activity, which has shown significant efficacy in pre-clinical and clinical studies. Curcumin stimulates cell death, triggers cycle arrest, ... -
Developing novel hydroxypropyl-β-cyclodextrin-based nanosponges as carriers for anticancer hydrophobic agents: Overcoming limitations of host-guest complexes in a comparative evaluation
Peimanfard, Shohreh; Zarrabi, Ali; Trotta, Francesco; Matencio, Adrián; Cecone, Claudio; Caldera, Fabrizio (PMC, 2022)This study aimed to design and fabricate novel hydroxypropyl-β-cyclodextrin-based hypercrosslinked polymers, called nanosponges, as carriers for anticancer hydrophobic agents and compare them with host–guest complexes of ... -
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance
Ashrafizadeh, Milad; Saebfar, Hamidreza; Gholami, Mohammad Hossein; Hushmandi, Kiavash; Zabolian, Amirhossein; Zarrabi, Ali (2022)Introduction: The application of doxorubicin (DOX) in cancer therapy has been limited due to its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the capacity for DOX delivery while promoting ... -
Editing SOX genes by CRISPR-Cas: current insights and future perspectives
Dehshahri, Ali; Biagioni, Alessio; Bayat, Hadi; Lee, E. Hui Clarissa; Hashemabadi, Mohammad; Samareh-Fekri, Hojjat; Zarrabi, Ali (MDPI, 2021)Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and its associated proteins (Cas) is an adaptive immune system in archaea and most bacteria. By repurposing these systems for use in eukaryote cells, a ... -
The effect of surface chemistry on anti-soiling properties of transparent perfluoroalkyl and alkyl modified silica coatings
Taheri, S.; Motlagh, F.H.; Dehestanizad, S.; Yahyaei, H.; Motallebzadeh, A.; Zarrabi, A.; Tehrani, A.G.; Khodabakhsh, M.; Makki, H. (Elsevier B.V., 2022)Various physical and chemical surface parameters, e.g., surface roughness and surface chemistry, contribute to anti-soiling (AS) properties. Nevertheless, the effect of surface chemistry has not been distinctly elucidated ... -
Electrospun nanocarriers for delivering natural products for cancer therapy
Mohammadinejad R.; Madamsetty V.S.; Kumar A.; Varzandeh M.; Dehshahri A.; Zarrabi A.; Sharififar F. (Elsevier Ltd, 2021)Background: Electrospinning has provided an excellent opportunity to develop nano-sized fibers with a broad range of applications, including nano-drug delivery systems for the treatment of cancer. This versatile and viable ... -
Exosomes as promising nanostructures in diabetes mellitus: from insulin sensitivity to ameliorating diabetic complications
Diabetes mellitus (DM) is among the chronic metabolic disorders that its incidence rate has shown an increase in developed and wealthy countries due to lifestyle and obesity. The treatment of DM has always been of interest, ... -
Exploiting urazole’s acidity for fabrication of hydrogels and ion-exchange materials
Hanay, Saltuk Bugra; Fallah, Ali; Senturk, Efsun; Yetim, Zeliha; Afghah, Ferdows; Yılmaz, Hülya; Culha, Mustafa; Koc, Bahattin (MDPI, 2021)In this study, the acidity of urazole (pKa 5–6) was exploited to fabricate a hydrogel in two simple and scalable steps. Commercially available poly(hexamethylene)diisocyanate was used as a precursor to synthesize an urazole ... -
EZH2 as a new therapeutic target in brain tumors: Molecular landscape, therapeutic targeting and future prospects
Paskeh, Mahshid Deldar Abad; Mehrabi, Atefeh; Gholami, Mohammad Hossein; Zabolian, Amirhossein; Ranjbar, Ehsan; Zarrabi, Ali (Elsevier, 2022)Brain tumors are responsible for high mortality and morbidity worldwide. The brain tumor treatment depends on identification of molecular pathways involved in progression and malignancy. Enhancer of zeste homolog 2 (EZH2) ...
