Browsing by Author "Zarrabi, Ali"
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Advances in aptamer-based drug delivery vehicles for cancer therapy
Ghasemi, Kousar; Darroudi, Mahdieh; Rahimmanesh, Ilnaz; Ghomi, Matineh; Hassanpour, Mahnaz; Sharifi, Esmaeel; Yousefiasl, Satar; Ahmadi, Sepideh; Zarrabi, Ali; Borzacchiello, Assunta; Rabiee, Mohammad; Paiva-Santos, Ana Cláudia; Rabiee, Navid (Elsevier, 2022)Overall, aptamers are special classes of nucleic acid-based macromolecules that are beginning to investigate because of their capability of avidity binding to a specific target for clinical use. Taking advantage of ... -
Advances in understanding the role of P-gp in doxorubicin resistance: molecular pathways, therapeutic strategies, and prospects
Mirzaei, Sepideh; Gholami, Mohammad Hossein; Hashemi, Farid; Zabolian, Amirhossein; Zarrabi, Ali (Elsevier, 2022)P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX) resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2, HIF-1α, miRNAs, and long noncoding (lnc)RNAs, ... -
AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: A pre-clinical and clinical investigation
Entezari, M.; Hashemi, D.; Taheriazam, A.; Zabolian, A.; Zabolian, A.; Fakhri, F.; Hashemi, M.; Hushmandi, K.; Ashrafizadeh, M.; Zarrabi, A.; Ertas, Y.N.; Mirzaei, S. (Elsevier, 2022)Diabetes mellitus (DM) is considered as a main challenge in both developing and developed countries, as lifestyle has changed and its management seems to be vital. Type I and type II diabetes are the main kinds and they ... -
Antimicrobial activity of blow spun PLA/gelatin nanofibers containing green synthesized silver nanoparticles against wound ınfection-causing bacteria
Sardareh, Elham Alinezhad; Shahzeidi, Moloud; Ardestani, Mohammad Taha Salmanifard; Mousavi-Khattat, Mohammad; Zarepour, Atefeh; Zarrabi, Ali (MDPI, 2022)One of the main challenges in wound healing is the wound infection due to various causes, of which moisture is the most important reason. Owing to this fact, wound dressings that can collect wound moisture in addition to ... -
Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic
Mostafavi, E.; Zarepour, A.; Barabadi, H.; Zarrabi, A.; Truong, L.B.; Medina-Cruz, D. (Elsevier B.V., 2022)The American Cancer Society estimated around 61,090 new cases of leukemia were diagnosed, and around 23,660 people died from this disease in the United States alone in 2021. Due to its burden on society, there is an unmet ... -
Cancer-Associated Fibroblasts Regulate the Plasticity of Breast Cancer Stemness through the Production of Leukemia Inhibitory Factor
Vaziri, N.; Shariati, L.; Zarrabi, Ali; Farazmand, A.; Javanmard, S.H. (Multidisciplinary Digital Publishing Institute (MDPI), 2021)Leukemia inhibitory factor (LIF), as a member of the interleukin-6 cytokine family, plays a complex role in solid tumors. However, the effect of LIF as a tumor microenvironment factor on plasticity control in breast cancer ... -
Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments
Varol, Aysegul; Sezen, Serap; Evcimen, Dilhan; Zarepour, Atefeh; Ulus, Gonul; Zarrabi, Ali; Badr, Gamal; Dastan, Sevgi Durna; Orbayoglu, Asya Gulistan (2022)Bee venom therapy is known as a traditional approach to curing many medical conditions such as arthritis, pain and rheumatism. Bee venom also provides promising potential for treating many cancers such as breast, lung, ... -
Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies
Paskeh, Mahshid Deldar Abad; Mirzaei, Sepideh; Gholami, Mohammad Hossein; Zarrabi, Ali; Zabolian, Amirhossein; Hashemi, Mehrdad; Hushmandi, Kiavash (Elsevier Science, 2021)Cervical cancer is the fourth common gynecologic cancer and is considered as second leading cause of death among women. Various strategies are applied in treatment of cervical cancer including radiotherapy, chemotherapy ... -
Characterization and optical properties of mechanochemically synthesized molybdenum-doped rutile nanoparticles and their electronic structure studies by density functional theory
Maleki-Ghaleh, H.; Shakeri, M.S.; Dargahi, Z.; Kavanlouei, M.; Kaveh Garabagh, H.; Moradpur-Tari, E.; Yourdkhani, A.; Fallah, A.; Zarrabi, A.; Koc, B.; Siadati, M.H. (Elsevier, 2022)The optical and electronic properties of molybdenum (Mo) doped rutile TiO2 prepared by the mechanochemical method were studied both experimentally and using density functional theory (DFT). The synthesized nanoparticles ... -
Chitosan-based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy
Ashrafizadeh, Milad; Hushmandi, Kiavash; Mirzaei, Sepideh; Bokaie, Saied; Bigham, Ashkan; Makvandi, Pooyan; Rabiee, Navid; Thakur, Vijay Kumar; Kumar, Alan Prem; Sharifi, Esmaeel; Varma, Rajender S.; Aref, Amir Reza; Wojnilowicz, Marcin; Zarrabi, Ali; Karimi-Maleh, Hassan; Voelcker, Nicolas H.; Mostafavi, Ebrahim; Orive, Gorka (AICHE Online Library, 2022)Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and ... -
Chitosan: a versatile bio-platform for breast cancer theranostics
Madamsetty, Vijay Sagar; Tavakol, Shima; Moghassemi, Saeid; Dadashzadeh, Arezoo; Schneible, John D.; Fatemi, Iman; Zarrabi, Ali (ELSEVIER, 2022)Breast cancer is considered one of the utmost neoplastic diseases globally, with a high death rate of patients. Over the last decades, many approaches have been studied to early diagnose and treat it, such as chemotherapy, ... -
Citrus genus and its waste utilization: a review on health-promoting activities and industrial application
Khan, Usman Mir; Mir, Usman; Muhammad Aadil, Rana; Shahid, Muhammad; Sezen, Serap; Zarrabi, Ali; Ozdemir, Betul; Sevindik, Mustafa (2021)Citrus fruits such as oranges, grapefruits, lemons, limes, tangerines, and mandarins, whose production is increasing every year with the rise of consumer demand, are among the most popular fruits cultivated throughout the ... -
Combination therapy using nanomaterials and stem cells to treat spinal cord injuries
Zarepour, Arezou; Ozturk, Ayca Bal; Koyuncu Irmak, Duygu; Yasayan, Gokcen; Gokmen, Aylin; Karaoz, Erdal; Zarepour, Atefeh; Zarrabi, Ali; Mostafavi, Ebrahim (Elsevier Science, 2022)As a part of the central nervous system, the spinal cord (SC) provides most of the communications between the brain and other parts of the body. Any damage to SC interrupts this communication, leading to serious ... -
The convergence of in silico approach and nanomedicine for efficient cancer treatment; in vitro investigations on curcumin loaded multifunctional graphene oxide nanocomposite structure
Paknia, Fatemeh; Mohabatkar, Hassan; Ahmadi-Zeidabadi, Meysam; Zarrabi, Ali (Editions de Sante, 2022)The development of multifunctional nano-carriers with the ability of stimuli responsive controlled drug release can address many of the challenges of current cancer therapies. Graphene oxide (GO)-based nanomaterials with ... -
Correction: The long and short non-coding RNAs modulating EZH2 signaling in cancer (Journal of Hematology & Oncology, (2022), 15, 1, (18), 10.1186/s13045-022-01235-1)
Mirzaei, Sepideh; Gholami, Mohammad Hossein; Hushmandi, Kiavash; Hashemi, Farid; Zabolian, Amirhossein; Canadas, Israel; Zarrabi, Ali; Nabavi, Noushin; Aref, Amir Reza; Crea, Francesco; Wang, Yuzhuo; Ashrafizadeh, Milad; Kumar, Alan Prem (BioMed Central Ltd, 2022)The original article [1] contained an error in co-author, Farid Hashemi’s name which has since been corrected. © 2022, The Author(s). -
Curcumin and its derivatives in cancer therapy: potentiating antitumor activity of cisplatin and reducing side effects
Abadi, Asal Jalal; Mirzaei, Sepideh; Mahabady, Mahmood Khaksary; Hashemi, Farid; Zabolian, Amirhossein; Hashemi, Fardin; Raee, Pourya; Zarrabi, Ali (WILEY, 2021)Curcumin is a phytochemical isolated from Curcuma longa with potent tumor-suppressor activity, which has shown significant efficacy in pre-clinical and clinical studies. Curcumin stimulates cell death, triggers cycle arrest, ... -
Customizing nano-chitosan for sustainable drug delivery
Mostafa Saeedi 1, Omid Vahidi 1, Mohammadreza Moghbeli 1, Sepideh Ahmadi 2, Mohsen Asadnia 3, Omid Akhavan 4, Farzad Seidi 5, Mohammad Rabiee 6, Mohammad Reza Saeb 7, Thomas J Webster 8, Rajender S Varma 9, Esmaeel Sharifi 10, Ali Zarrabi 11, Navid Rabiee 12 Affiliations collapse; Saeedi, Mostafa; Vahidi, Omid; Moghbeli, Mohammadreza; Ahmadi, Sepideh; Asadnia, Mohsen; Akhavan, Omid; Seidi, Farzad; Rabiee, Mohammad; Saeb, Mohammad Reza; Webster, Thomas J.; Zarrabi, Ali; Rabiee, Navid; Varma, Rajender S.; Sharifi, Esmaeel (PMC, 2022)Chitosan is a natural polymer with acceptable biocompatibility, biodegradability, and mechanical stability; hence, it has been widely appraised for drug and gene delivery applications. However, there has been no comprehensive ... -
Developing novel hydroxypropyl-β-cyclodextrin-based nanosponges as carriers for anticancer hydrophobic agents: Overcoming limitations of host-guest complexes in a comparative evaluation
Peimanfard, Shohreh; Zarrabi, Ali; Trotta, Francesco; Matencio, Adrián; Cecone, Claudio; Caldera, Fabrizio (PMC, 2022)This study aimed to design and fabricate novel hydroxypropyl-β-cyclodextrin-based hypercrosslinked polymers, called nanosponges, as carriers for anticancer hydrophobic agents and compare them with host–guest complexes of ... -
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance
Ashrafizadeh, Milad; Saebfar, Hamidreza; Gholami, Mohammad Hossein; Hushmandi, Kiavash; Zabolian, Amirhossein; Zarrabi, Ali (2022)Introduction: The application of doxorubicin (DOX) in cancer therapy has been limited due to its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the capacity for DOX delivery while promoting ... -
Editing SOX genes by CRISPR-Cas: current insights and future perspectives
Dehshahri, Ali; Biagioni, Alessio; Bayat, Hadi; Lee, E. Hui Clarissa; Hashemabadi, Mohammad; Samareh-Fekri, Hojjat; Zarrabi, Ali (MDPI, 2021)Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and its associated proteins (Cas) is an adaptive immune system in archaea and most bacteria. By repurposing these systems for use in eukaryote cells, a ...
