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Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer lines
(Taylor & Francis Inc, 2019)
1,4-Naphthoquinones (1,4-NQ) have been reported to possess a variety of pharma-cological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic, and anticancer effects. In this ...
The MTT viability assay yields strikingly false-positive viabilities although the cells are killed by some plant extracts
(Tubitak Scientific & Technical Research Council Turkey, 2017)
The MTT assay is one of the often used cell viability/cytotoxicity assays. However, when the methanol extracts of plants are used to test their cytotoxic potential, interference may occur, resulting in false-positive ...
Identification of microenvironmental regulation and therapeutic targeting of oncogenic eEF2K in pancreatic cancer
(Wiley, 2019)
Eukaryotic elongation factor 2 kinase (eEF2K) is overexpressed
in cancer cells and its overexpression is correlated with poor
prognosis in several types of cancer. It has been known that pancreatic
cancer (PaCa) has a ...
Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation
(Bentham Science Publ Ltd, 2019)
Background: Prostate cancer is one of the most common cancer types and it is the sixth leading cause of cancer-related death in men worldwide. Even though novel treatment modalities have been developed, it still a ...
Identification of microenvironmental regulation and therapeutic targeting of ongenic EF-2 kinase in pancreatic cancer
(Science Direct, 2018)
Introduction
Pancreatic cancer (PaCa) is one of the most aggressive and deadliest cancer with 6 months average survival rate. Recent studies indicate that the tumour microenvironment (TME) plays an important role in all ...
Cancer stem cells : root of the evil
(Begell House Inc., 2019)
Cancer stem cells (CSCs) have been one of the most attractive research areas over the last two decades due to their important roles in aggressive tumor behaviors. Although CSCs are usually a small subpopulation of tumors ...
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
(Academic Press Ltd- Elsevier Science Ltd, 2018)
Several natural products have been suggested as effective agents for the treatment of cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy hypothesis, it is worth investigating the ...
