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A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer

Cevatemre, Buse; Erkisa Genel, Merve; Aztopal, Nazlihan; Karakas Zeybek, Didem; Alper, Pinar; Tsimplouli, Chrisiida; Sereti, Evangelia; Dimas, Konstantinos; Armutak, Elif I. Ikitimur; Gurevin, Ebru Gurel; Uvez, Ayca; Mori, Mattia; Berardozzi, Simone; Ingallina, Cinzia; D'Acquarica, Ilaria; Botta, Bruno; Ozpolat, Bulent; Ulukaya, Engin (Academic Press Ltd- Elsevier Science Ltd, 2018)

Several natural products have been suggested as effective agents for the treatment of cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy hypothesis, it is worth investigating the ...

Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells

Aztopal, Nazlihan; Erkisa Genel, Merve; Ertürk, Elif; Ulukaya, Engin; Tokullugil, Asuman Hatice; Ari, Ferda (Elsevier Ireland Ltd, 2018)

Cancer stem-like cells (CSCs) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, give rise to metastases and lead to disease relapse because of an acquired resistance to apoptosis. Especially, ...

Usnea filipendula induces apoptosis in human colon cancer cell lines

Disoma, C.; Erkisa Genel, Merve; Oran, S.; Alioglu, I.; Ulukaya, Engin; Ari, F. (Wolters Kluwer Medknow Publications, 2018)

Lichens are complex organisms living in a symbiotic relationship with fungi and algae have recently received special interest in cancer research. The cytotoxic activities of Usnea filipendula Stirt. lichen extract was ...

Structural studies and cytotoxic activity of a new dinuclear coordination compound of palladium(II)-2,2:6,2-terpyridine with rigid dianionic 1,2,4-triazole-3-sulfonate linker

Buyukeksi, Sebile Isik; Erkisa Genel, Merve; Şengül, Abdurrahman; Ulukaya, Engin; Oral, Arzu Yilmaztepe (Wiley, 2018)

A new dinuclear coordination compound of palladium(II), [Pd-2(terpy)(2)(-tas-N-1,N-4)]SO(4)11H(2)O (1), was synthesized by tethering a doubly deprotonated 1,2,4-triazole-3-sulfonate (tas) linker generated in situ via ...

Dual inhibition of Wnt/beta-catenin signaling and histone deacetylation as a new strategy to eliminate breast cancer stem cells by augmentation of apoptosis

Aztopal, Nazlihan; Erkisa Genel, Merve; Ari, F.; Dere, E.; Ulukaya, Engin (Wiley, 2018)

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Kalsitriol ve doksorubisin kombinasyonunun MCF7 üzerine olası anti kanser etkilerinin araştırılması

Bildiren, Ozge; Cevatemre, Buse; Ay, Ebru Nur; Ozen, Gunes; Hepokur, Ceylan; Erkisa Genel, Merve; Ulukaya, Engin (DergiPark, 2018)

Amaç: Bu çalışmada amacımız, belirli bir dozun üzerinde kardiyak yan etkileri oldukça fazla olan ve meme kanseri tedavisinde kullanılan kemoterapötiklerden doksorubisinin, tedavide kullanım miktarlarını azaltmayı ve ...

Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA

Yilmaz, Veysel T.; Icsel, Ceyda; Turgut, Omer R.; Aygun, Muhittin; Erkisa Genel, Merve; Turkdemir, Mehmet H.; Ulukaya, Engin (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)

A series of new Pt(II) saccharinate complexes containing PR3 ligands (PPh3, PPh2Cy, PPhCy2 and PCy3) with progressive phenyl (Ph) replacement by cyclohexyl (Cy) were synthesized and structurally characterized by lR, NMR, ...

Pd(II) and Pt(II) saccharinate complexes of bis(diphenylphosphino) propane/butane: synthesis, structure, antiproliferative activity and mechanism of action

Yilmaz, Veysel T.; Icsel, Ceyda; Aygun, Muhittin; Erkisa Genel, Merve; Ulukaya, Engin (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)

[M(sac)(2)(dppp)] (1 and 2), [M(dppp)(2)](sac)(2) (3 and 4) and [M(sac)(2)(dppb)] (5 and 6) complexes, where M = Pd-II (1, 3 and 5) and Pt-II (2, 4 and 6), sac = saccharinate, dppp = 1,3-bis(diphenylphosphino)propane and ...