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Effects of novel targeted anticancer drugs on cytotoxicity, apoptosis, angiogenesis, EMT, drug resistance and autophagic mechanism
(Oxford Univ Press, 2019)
Background: Metastatic coloncancer has asurvival rate less than %5 despite the use of effective chemotherapeutic regimen. Prognosticand predictiveimportance of EGFR is still contradictivein coloncancer. Tyrosine kinase ...
A palladium(II)-saccharinate complex of terpyridine exerts higher anticancer potency and less toxicity than cisplatin in a mouse allograft model
(Lippincott Williams & Wilkins, 2017)
The main aim of this study is to assess the safety and antitumor efficacy of a palladium(II) (Pd)-saccharinate complex with terpyridine. To characterize the Pd(II) complex in vitro, its cytotoxicity was evaluated using a ...
A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer
(Pergamon-Elsevier Science Ltd, 2017)
Recent accumulating evidence has supported the notion that tumors have hierarchically organized heterogeneous cell populations and a small subpopulation of cells, termed cancer stem cells (CSCs), are responsible for tumor ...
Cytotoxic effect of conyza canadensis (L.) cronquist on human lung cancer cell lines
(Turkish Pharmacists Assoc, 2016)
Asteraceae family plants are receiving great attention because they have potential anticancer activity. Therefore, in this study, the cytotoxic effect of Conyza canadensis (L.) Cronquist (Asteraceae) were tested against ...
The effect of NOTCH, IL-1 and LEPTIN (NILCO) inhibition in xenograft colorectal cancer
(Wiley, 2019)
Questions: Studies in various cancer tissues have shown that Notch, IL-1 and leptin interaction (NILCO) play a role in the
proliferation, migration and expression of proangogenic molecules. It has been suggested that ...
Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: synthesis, characterization and anticancer activity
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)
Cancer treatment still requires new compounds to be discovered. Chalcone and its derivatives exhibit anticancer potential in different cancer cells. A new series of benzofuran substituted chalcone derivatives was synthesized ...
Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells
(Elsevier, 2019)
Background: It has been known epidermal growth factor receptor (EGFR) frequently overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a poor prognosis and inhibition frequently induces ...
Bioassay-guided isolation of cytotoxic compounds from chrysophthalmum montanum (DC.) boiss
(Pergamon-Elsevier Science Ltd, 2019)
Bioassay-guided isolation of the 80% methanol extract of the aerial parts of Chrysophthalmum montanum (DC.) Boiss. (Asteraceae) led to the isolation of four known guaianolide-type sesquiterpene lactones, 6 alpha-acetoxy-4 ...
Protoflavone-chalcone hybrids exhibit enhanced antitumor action through modulating redox balance, depolarizing the mitochondrial membrane, and inhibiting ATR-dependent signaling
(Mdpi, 2020)
Hybrid compounds combine fragments with complementary targets to achieve a common pharmacological goal. This approach represents an increasingly popular strategy for drug discovery. In this work, we aimed to design antitumor ...
Combination of histone deacetylase inhibitor with Cu(II) 5,5- diethylbarbiturate complex induces apoptosis in breast cancer stem cells: a promising novel approach
(2021)
Background: Cancer stem cells (CSC) are subpopulation within the tumor that acts a part in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes ...
