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Highly promising antitumor agent of a novel Platinum(II) complex bearing a tetradentate chelating ligand 

Yilmaz, Ismail; Akar, Remzi Okan; Erkisa Genel, Merve; Selvi, Selin; Şengül, Abdurrahman; Ulukaya, Engin (Amer Chemical Soc, 2020)
A new mononuclear cationic platinum(II) coordination compound with 6,6'-bis(NH-benzimidazol-2-yl)-2,2'-bipyridine (L) ligand having N-4-tetradentate binding pocket [Pt(L)]-Cl-2.2H(2)O (Complex 1) was synthesized and ...
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A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex 

Erkisa Genel, Merve; Aydinlik S.; Cevatemre B.; Aztopal, Nazlihan; Akar, Remzi Okan; Celikler S.; Yilmaz, V.T; Ari, F.; Ulukaya, Engin (Elsevier B.V., 2020)
Autophagy is a catabolic process for cells that can provide energy sources and allows cancer cells to evade cell death. Therefore, studies on the combination of autophagy inhibitors with drugs are increasing as a new ...
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Trans-Pd/Pt(II) saccharinate complexes with a phosphine ligand: Synthesis, cytotoxicity and structure-activity relationship 

Icsel, Ceyda; Yilmaz, Veysel T.; Aygun, Muhittin; Ulukaya, Engin (Pergamon-Elsevier Science Ltd, 2020)
New trans-[Pd(sac)(2)(PPhMe2)(DMSO)]center dot H2O (Pd) and trans-[Pt(sac)(2)(PPhMe2)(2)]center dot H2O (Pt) complexes (sac = saccharinate and PPhMe 2 = dimethylphenylphosphine) were synthesized and characterized by elemental ...
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Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activity 

Genckal, Hasene; Erkisa Genel, Merve; Alper, Pinar; Sahin, Saliha; Ulukaya, Engin; Ari, Ferda (Springer, 2020)
In this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2 '-bipyiridine) ligands. The obtained Ni(II) and Co(II) complexes are new and the ...
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Protoflavone-chalcone hybrids exhibit enhanced antitumor action through modulating redox balance, depolarizing the mitochondrial membrane, and inhibiting ATR-dependent signaling 

Latif, Ahmed Dhahir; Jernei, Tamas; Podolski-Renic, Ana; Kuo, Ching-Ying; Vagvolgyi, Mate; Girst, Gabor; Zupko, Istvan; Develi, Elif Sedef; Ulukaya, Engin; Wang, Hui-Chun; Pesic, Milica; Csampai, Antal; Hunyadi, Attila (Mdpi, 2020)
Hybrid compounds combine fragments with complementary targets to achieve a common pharmacological goal. This approach represents an increasingly popular strategy for drug discovery. In this work, we aimed to design antitumor ...
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Toxicity assessment of Hypericum olympicum subsp. olympicum L. on human lymphocytes and breast cancer cell lines 

Balikci, Necmiye; Sarimahmut, Mehmet; Ari, Ferda; Aztopal, Nazlihan; Ozel, Mustafa Zafer; Ulukaya, Engin; Celikler, Serap (Univ South Bohemia, 2020)
There is a limited number of studies about the constituents of Hypericum olympicum subsp. olympicum and its genotoxic and cytotoxic potency. We examined the possible antigenotoxic/genotoxic properties of methanolic extract ...
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Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer lines 

Gokmen, Zeliha; Onan, Mehmet Erdi; Deniz, Nahide Gulsah; Karakas Zeybek, Didem; Ulukaya, Engin (Taylor & Francis Inc, 2019)
1,4-Naphthoquinones (1,4-NQ) have been reported to possess a variety of pharma-cological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic, and anticancer effects. In this ...
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Structures and anticancer activity of chlorido platinum(II) saccharinate complexes with mono- and dialkylphenylphosphines 

Icsel, Ceyda; Yilmaz, Veysel T.; Cevatemre, Buse; Aygun, Muhittin; Ulukaya, Engin (Elsevier Science Inc, 2019)
cis-[PtCl(sac)(PPh2Me)(2)] (1), cis-[PtCl(sac)(PPhMe2)(2)] (2), trans-[PtCl(sac)(PPh2Et)(2)] (3) and trans- [PtCl(sac) (PPhEt2)(2)] (4) complexes (sac = saccharinate) were synthesized and characterized by elemental analysis ...
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Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect 

Buz, Pelin Turhan; Duman, Fatma Demir; Erkisa Genel, Merve; Demirci, Gozde; Ari, Ferda; Ulukaya, Engin; Acar, Havva Yagci (Future Medicine Ltd, 2019)
Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their ...
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Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells 

Aydinlik, Seyma; Dere, Egemen; Ulukaya, Engin (Elsevier, 2019)
Background: It has been known epidermal growth factor receptor (EGFR) frequently overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a poor prognosis and inhibition frequently induces ...
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Ari, Ferda (18)Erkisa Genel, Merve (15)Aztopal, Nazlihan (9)Cevatemre, Buse (9)Yilmaz, Veysel T. (8)Icsel, Ceyda (7)Karakas Zeybek, Didem (7)Aygun, Muhittin (6)Erkisa, Merve (6)... View MoreSubjectApoptosis (17)Cytotoxicity (16)Breast Cancer (5)Saccharinate (5)Autophagy (4)Anticancer Activity (3)Dna Damage (3)Phosphine (3)1 (2)Ag2s Quantum Dots (2)... View MoreDate Issued2019 (15)2018 (10)2020 (10)2017 (9)2016 (1)2021 (1)Has File(s)true (44)false (2)

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