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A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex
(Elsevier B.V., 2020)
Autophagy is a catabolic process for cells that can provide energy sources and allows cancer cells to evade cell death. Therefore, studies on the combination of autophagy inhibitors with drugs are increasing as a new ...
Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect
(Future Medicine Ltd, 2019)
Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their ...
Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells
(Elsevier, 2019)
Background: It has been known epidermal growth factor receptor (EGFR) frequently overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a poor prognosis and inhibition frequently induces ...
Cytotoxic and genotoxic effects of an endemic plant of Turkey salvia kronenburgii on breast cancer cell lines
(Wolters Kluwer Medknow Publications, 2019)
Context: The natural products derived from plants are the important sources that can be used for breast cancer treatment. Salvia species and their derived products were recommended as potential antitumor substances. Aim: ...
Identification of microenvironmental regulation and therapeutic targeting of oncogenic eEF2K in pancreatic cancer
(Wiley, 2019)
Eukaryotic elongation factor 2 kinase (eEF2K) is overexpressed
in cancer cells and its overexpression is correlated with poor
prognosis in several types of cancer. It has been known that pancreatic
cancer (PaCa) has a ...
Structures and anticancer activity of chlorido platinum(II) saccharinate complexes with mono- and dialkylphenylphosphines
(Elsevier Science Inc, 2019)
cis-[PtCl(sac)(PPh2Me)(2)] (1), cis-[PtCl(sac)(PPhMe2)(2)] (2), trans-[PtCl(sac)(PPh2Et)(2)] (3) and trans- [PtCl(sac) (PPhEt2)(2)] (4) complexes (sac = saccharinate) were synthesized and characterized by elemental analysis ...
Synthesis, characterization, anticancer and antioxidant activity of new nickel(II) and copper(II) flavonoid complexes
(Elsevier, 2019)
Flavonoids are natural products which are known to have biological activity for human health. In this study, new mixed ligand complexes of Ni(II) and Cu(II) were synthesized by using flavonoid (quercetin or naringenin) and ...
Effects of novel targeted anticancer drugs on cytotoxicity, apoptosis, angiogenesis, EMT, drug resistance and autophagic mechanism
(Oxford Univ Press, 2019)
Background: Metastatic coloncancer has asurvival rate less than %5 despite the use of effective chemotherapeutic regimen. Prognosticand predictiveimportance of EGFR is still contradictivein coloncancer. Tyrosine kinase ...
The effect of NOTCH, IL-1 and LEPTIN (NILCO) inhibition in xenograft colorectal cancer
(Wiley, 2019)
Questions: Studies in various cancer tissues have shown that Notch, IL-1 and leptin interaction (NILCO) play a role in the
proliferation, migration and expression of proangogenic molecules. It has been suggested that ...
Trans-Pd/Pt(II) saccharinate complexes with a phosphine ligand: Synthesis, cytotoxicity and structure-activity relationship
(Pergamon-Elsevier Science Ltd, 2020)
New trans-[Pd(sac)(2)(PPhMe2)(DMSO)]center dot H2O (Pd) and trans-[Pt(sac)(2)(PPhMe2)(2)]center dot H2O (Pt) complexes (sac = saccharinate and PPhMe 2 = dimethylphenylphosphine) were synthesized and characterized by elemental ...
