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Highly promising antitumor agent of a novel Platinum(II) complex bearing a tetradentate chelating ligand 

Yilmaz, Ismail; Akar, Remzi Okan; Erkisa Genel, Merve; Selvi, Selin; Şengül, Abdurrahman; Ulukaya, Engin (Amer Chemical Soc, 2020)
A new mononuclear cationic platinum(II) coordination compound with 6,6'-bis(NH-benzimidazol-2-yl)-2,2'-bipyridine (L) ligand having N-4-tetradentate binding pocket [Pt(L)]-Cl-2.2H(2)O (Complex 1) was synthesized and ...
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A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex 

Erkisa Genel, Merve; Aydinlik S.; Cevatemre B.; Aztopal, Nazlihan; Akar, Remzi Okan; Celikler S.; Yilmaz, V.T; Ari, F.; Ulukaya, Engin (Elsevier B.V., 2020)
Autophagy is a catabolic process for cells that can provide energy sources and allows cancer cells to evade cell death. Therefore, studies on the combination of autophagy inhibitors with drugs are increasing as a new ...
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Effective and new potent drug combination: histone deacetylase and Wnt/beta-catenin pathway inhibitors in lung carcinoma cells 

Akgun, Oguzhan; Erkisa Genel, Merve; Ari, Ferda (Wiley, 2019)
Lung cancer is the most commonly diagnosed cancer worldwide with a high mortality rate. In this study, the therapeutic effect of combination valproic acid and niclosamide was investigated on human lung cancer cell line. ...
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Effects of intrathecai verapamil on cerebral vasospasm in experimental rat study 

Akkaya, Enes; Evran, Sevket; Calis, Fatih; Cevik, Serdar; Hanimoglu, Hakan; Seyithanoglu, Mehmet Hakan; Katar, Salim; Karatas, Ersin; Kocyigit, Abdurrahim; Saglam, Mustafa Yasin; Hatiboglu, Mustafa Aziz; Kaynar, Mehmet Yasar (Elsevier Science Inc, 2019)
BACKGROUND: Verapamil a calcinarn channel blacker, has shown promising results on cerebral vasospasm. However, it has not yet been accepted for treatment or prevention purposes because of the associated side effects, ...
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Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect 

Buz, Pelin Turhan; Duman, Fatma Demir; Erkisa Genel, Merve; Demirci, Gozde; Ari, Ferda; Ulukaya, Engin; Acar, Havva Yagci (Future Medicine Ltd, 2019)
Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their ...
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Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells 

Aydinlik, Seyma; Dere, Egemen; Ulukaya, Engin (Elsevier, 2019)
Background: It has been known epidermal growth factor receptor (EGFR) frequently overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a poor prognosis and inhibition frequently induces ...
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Silver nanoparticle/capecitabine for breast cancer cell treatment 

Hepokur, Ceylan; Kariper, Ishak Afsin; Misir, Sema; Ay, Ebrunur; Tunoglu, Servet; Ersez, Mediha Suleymanoglu; Zeybek, Umit; Kuruca, Serap Erdem; Yaylim, Ilhan (Pergamon-Elsevier Science Ltd, 2019)
This study aimed to evaluate antiproliferative and proapoptotic effects of Capecitabine bonded silver particles on human breast cancer cells (MCF-7). Different sizes of Ag NPs (in sizes 5, 10, 15, 30 nm) were synthesized. ...
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Usnea filipendula induces apoptosis in human colon cancer cell lines 

Disoma, C.; Erkisa, Merve; Oran, S.; Alioglu, I.; Ulukaya, Engin; Ari, F. (Wolters Kluwer Medknow Publications, 2018)
Lichens are complex organisms living in a symbiotic relationship with fungi and algae have recently received special interest in cancer research. The cytotoxic activities of Usnea filipendula Stirt. lichen extract was ...
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Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis 

Ozturk, Sule; Erkisa Genel, Merve; Oran, Oran; Ulukaya, Engin; Celikler, Serap; Ari, Ferda (Taylor and Francis Ltd, 2019)
Successful cancer treatment still requires new complexes or compounds from natural sources. Therefore, we investigated anti-growth/apoptotic effects of methanol extracts of the lichen species (Xanthoparmelia somloensis ...
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Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation 

Karakas Zeybek, Didem; Cevatemre, Buse; Oral, Arzu Y.; Yilmaz, Veysel T.; Ulukaya, Engin (Bentham Science Publ Ltd, 2019)
Background: Prostate cancer is one of the most common cancer types and it is the sixth leading cause of cancer-related death in men worldwide. Even though novel treatment modalities have been developed, it still a ...
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AuthorUlukaya, Engin (17)Ari, Ferda (10)Erkisa Genel, Merve (9)Aztopal, Nazlihan (4)Cevatemre, Buse (4)Akar, Remzi Okan (3)Erkisa, Merve (3)Yilmaz, Veysel T. (3)Acar, Havva Yagci (2)Ari, F. (2)... View MoreSubject
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Cytotoxicity (8)Apoptoz (5)Autophagy (4)Sitotoksisite (4)Breast Cancer (3)Prostate Cancer (3)Valproic Acid (3)Anticancer Activity (2)Breast Cancer Stem Cell (2)... View MoreDate Issued2019 (10)2020 (8)2017 (4)2018 (4)2021 (1)Has File(s)true (25)false (2)

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