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A palladium(II)-saccharinate complex of terpyridine exerts higher anticancer potency and less toxicity than cisplatin in a mouse allograft model 

Cetin, Yuksel; Adiguzel, Zelal; Polat, Hivda U.; Akkoc, Tolga; Tas, Arzu; Cevatemre, Buse; Celik, Gokalp; Carikci, Baris; Yilmaz, Veysel T.; Ulukaya, Engin; Acilan, Ceyda (Lippincott Williams & Wilkins, 2017)
The main aim of this study is to assess the safety and antitumor efficacy of a palladium(II) (Pd)-saccharinate complex with terpyridine. To characterize the Pd(II) complex in vitro, its cytotoxicity was evaluated using a ...
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A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer 

Aztopal, Nazlihan; Karakas, Didem; Cevatemre, Buse; Ari, Ferda; Icsel, Ceyda; Daidone, Maria G.; Ulukaya, Engin (Pergamon-Elsevier Science Ltd, 2017)
Recent accumulating evidence has supported the notion that tumors have hierarchically organized heterogeneous cell populations and a small subpopulation of cells, termed cancer stem cells (CSCs), are responsible for tumor ...
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Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: synthesis, characterization and anticancer activity 

Coskun, Demet; Erkisa, Merve; Ulukaya, Engin; Coskun, Mehmet Fatih; Ari, Ferda (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)
Cancer treatment still requires new compounds to be discovered. Chalcone and its derivatives exhibit anticancer potential in different cancer cells. A new series of benzofuran substituted chalcone derivatives was synthesized ...
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Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells 

Aydinlik, Seyma; Dere, Egemen; Ulukaya, Engin (Elsevier, 2019)
Background: It has been known epidermal growth factor receptor (EGFR) frequently overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a poor prognosis and inhibition frequently induces ...
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Soloxolone methyl, as a 18βH-glycyrrhetinic acid derivate, may result in endoplasmic reticulum stress to induce apoptosis in breast cancer cells 

Alper, Pinar; Salomatina, Oksana V.; Salakhutdinov, Nariman F.; Ulukaya, Engin; Ari, Ferda (Elsevier Ltd, 2021)
Being one of the leading causes of cancer death among women, various chemotherapeutic agents isolated from natural compounds are used in breast cancer treatment and consequently studies to develop new drugs still continue. ...
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Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines 

Tunc, Duygu; Dere, Egemen; Karakas, Didem; Cevatemre, Buse; Yilmaz, Veysel Turan; Ulukaya, Engin (Pergamon-Elsevier Science Ltd, 2017)
Metal-based chemotherapeutics such as cisplatin are widely used treatment of lung cancer which is the major cause of cancer-related mortality worldwide. Recent studies demonstrated that novel metal-based compounds have ...
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Preparation and characterization of palladium derivate-loaded micelle formulation in vitro as an innovative therapy option against non-small cell lung cancer cells 

Erkisa, Merve; Ari, Ferda; Buyukkoroglu, Gulay; Senel, Bedriye; Yilmaz, Veysel Turan; Ulukaya, Engin (WILEY, 2021)
Nanoparticles have been used in cancer treatments to target tumor and reduce side effects. In this study, we aimed to increase the effectiveness of palladium(II) complex [PdCl(terpy)](sac)·2H2O, which previously showed ...
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Palladium (II) complex enhances ROS-dependent apoptotic effects via autophagy inhibition and disruption of multiple signaling pathways in colorectal cancer cells 

Aydinlik, Seyma; Erkisa Genel, Merve; Ari, Ferda; Celikler, Serap; Ulukaya, Engin (2021)
Background: Inhibition of autophagy is reported to be a therapeutically effective strategy in overcoming the resistance that is a deadly outcome in cancer. One of the most common reasons for chemo-resistance to treatment ...
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Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA 

Yilmaz, Veysel T.; Icsel, Ceyda; Turgut, Omer R.; Aygun, Muhittin; Erkisa Genel, Merve; Turkdemir, Mehmet H.; Ulukaya, Engin (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)
A series of new Pt(II) saccharinate complexes containing PR3 ligands (PPh3, PPh2Cy, PPhCy2 and PCy3) with progressive phenyl (Ph) replacement by cyclohexyl (Cy) were synthesized and structurally characterized by lR, NMR, ...
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Etoposide loaded SPION-PNIPAM nanoparticles improve the in vitro therapeutic outcome on metastatic prostate cancer cells via enhanced apoptosis 

Erkisa Genel, Merve; Ari, Ferda; Ulku, Irem; Khodadust, Rouhollah; Yar, Yasemin; Acar, Havva Yagci; Ulukaya, Engin (2020)
Prostate cancer is among the leading causes of death worldwide because its metastatic form is a deadly disease. Therefore, the development of new chemotherapeutics is of immense importance. Nanoparticle technology seems ...
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Ari, Ferda (11)Erkisa Genel, Merve (6)Cevatemre, Buse (5)Erkısa Genel, Merve (4)Akar, Remzi Okan (3)Aztopal, Nazlıhan (3)Erkisa, Merve (3)Acar, Havva Yagci (2)Aydinlik, Seyma (2)... View MoreSubject
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Cytotoxicity (5)Autophagy (3)Anticancer Activity (2)Breast Cancer (2)Breast Cancer Stem Cell (2)Cancer Cell Death (2)Dna Damage (2)Epigenetic Modulators (2)Metal-Based Compounds (2)... View MoreDate Issued2021 (6)2017 (4)2019 (4)2018 (3)2020 (3)Full Text StatusWith Full Text (19)Without Full Text (1)

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