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Palladium (II) complex enhances ROS-dependent apoptotic effects via autophagy inhibition and disruption of multiple signaling pathways in colorectal cancer cells

Aydinlik, Seyma; Erkisa Genel, Merve; Ari, Ferda; Celikler, Serap; Ulukaya, Engin (2021)

Background: Inhibition of autophagy is reported to be a therapeutically effective strategy in overcoming the resistance that is a deadly outcome in cancer. One of the most common reasons for chemo-resistance to treatment ...

Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells

Aztopal, Nazlihan; Erkisa Genel, Merve; Ertürk, Elif; Ulukaya, Engin; Tokullugil, Asuman Hatice; Ari, Ferda (Elsevier Ireland Ltd, 2018)

Cancer stem-like cells (CSCs) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, give rise to metastases and lead to disease relapse because of an acquired resistance to apoptosis. Especially, ...

Etoposide loaded SPION-PNIPAM nanoparticles improve the in vitro therapeutic outcome on metastatic prostate cancer cells via enhanced apoptosis

Erkisa Genel, Merve; Ari, Ferda; Ulku, Irem; Khodadust, Rouhollah; Yar, Yasemin; Acar, Havva Yagci; Ulukaya, Engin (2020)

Prostate cancer is among the leading causes of death worldwide because its metastatic form is a deadly disease. Therefore, the development of new chemotherapeutics is of immense importance. Nanoparticle technology seems ...

Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis

Ozturk, Sule; Erkisa Genel, Merve; Oran, Oran; Ulukaya, Engin; Celikler, Serap; Ari, Ferda (Taylor and Francis Ltd, 2021)

Successful cancer treatment still requires new complexes or compounds from natural sources. Therefore, we investigated anti-growth/apoptotic effects of methanol extracts of the lichen species (Xanthoparmelia somloensis ...

Effective and new potent drug combination: histone deacetylase and Wnt/beta-catenin pathway inhibitors in lung carcinoma cells

Akgun, Oguzhan; Erkisa Genel, Merve; Ari, Ferda (Wiley, 2019)

Lung cancer is the most commonly diagnosed cancer worldwide with a high mortality rate. In this study, the therapeutic effect of combination valproic acid and niclosamide was investigated on human lung cancer cell line. ...

Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect

Buz, Pelin Turhan; Duman, Fatma Demir; Erkisa Genel, Merve; Demirci, Gozde; Ari, Ferda; Ulukaya, Engin; Acar, Havva Yagci (Future Medicine Ltd, 2019)

Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their ...