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Identification of microenvironmental regulation and therapeutic targeting of oncogenic eEF2K in pancreatic cancer
Eukaryotic elongation factor 2 kinase (eEF2K) is overexpressed in cancer cells and its overexpression is correlated with poor prognosis in several types of cancer. It has been known that pancreatic cancer (PaCa) has a ...
Cancer stem cells : root of the evil
(Begell House Inc., 2019)
Cancer stem cells (CSCs) have been one of the most attractive research areas over the last two decades due to their important roles in aggressive tumor behaviors. Although CSCs are usually a small subpopulation of tumors ...
Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer lines
(Taylor & Francis Inc, 2019)
1,4-Naphthoquinones (1,4-NQ) have been reported to possess a variety of pharma-cological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic, and anticancer effects. In this ...
Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation
(Bentham Science Publ Ltd, 2019)
Background: Prostate cancer is one of the most common cancer types and it is the sixth leading cause of cancer-related death in men worldwide. Even though novel treatment modalities have been developed, it still a ...