Now showing items 1-5 of 5
Wnt/β-Catenin signaling as a driver of hepatocellular carcinoma progression: an emphasis on molecular pathways
(Dove Medical Press, 2021)
Liver cancers cause a high rate of death worldwide and hepatocellular carcinoma (HCC) is considered as the most common primary liver cancer. HCC remains a challenging disease to treat. Wnt/β-catenin signaling pathway is ...
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance
Introduction: The application of doxorubicin (DOX) in cancer therapy has been limited due to its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the capacity for DOX delivery while promoting ...
Non-coding RNAs and macrophage interaction in tumor progression
(Elsevier Ireland Ltd, 2022)
The macrophages are abundantly found in TME and their M2 polarization is in favor of tumor malignancy. On the other hand, non-coding RNAs (ncRNAs) can modulate macrophage polarization in TME to affect cancer progression. ...
Molecular landscape of LncRNAs in prostate cancer: A focus on pathways and therapeutic targets for intervention
Background: One of the most malignant tumors in men is prostate cancer that is still incurable due to its heterog‑ enous and progressive natures. Genetic and epigenetic changes play signifcant roles in its development. ...
Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches
The site-specific delivery of antitumor agents is of importance for providing effective cancer suppression. Poor bioavailability of anticancer compounds and the presence of biological barriers prevent their accumulation ...