Now showing items 1-6 of 6
Identification of microenvironmental regulation and therapeutic targeting of oncogenic eEF2K in pancreatic cancer
Eukaryotic elongation factor 2 kinase (eEF2K) is overexpressed in cancer cells and its overexpression is correlated with poor prognosis in several types of cancer. It has been known that pancreatic cancer (PaCa) has a ...
A novel 1,4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cells
(Tubitak Scientific & Technical Research Council Turkey, 2019)
Breast cancer is the most-diagnosed cancer type among women. The triple-negative subtype is an especially aggressive type of breast cancer. Although chemotherapy is almost the only option for the treatment of triple-negative ...
Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation
(Bentham Science Publ Ltd, 2019)
Background: Prostate cancer is one of the most common cancer types and it is the sixth leading cause of cancer-related death in men worldwide. Even though novel treatment modalities have been developed, it still a ...
Prognostic gene alterations and clonal changes in childhood B-ALL
(Pergamon-Elsevier Science Ltd, 2019)
Genomic profiles of leukemia patients lead to characterization of variations that provide the molecular classification of risk groups, prediction of clinical outcome and therapeutic decisions. In this study, we examined ...
Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer lines
(Taylor & Francis Inc, 2019)
1,4-Naphthoquinones (1,4-NQ) have been reported to possess a variety of pharma-cological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic, and anticancer effects. In this ...
Cancer stem cells : root of the evil
(Begell House Inc., 2019)
Cancer stem cells (CSCs) have been one of the most attractive research areas over the last two decades due to their important roles in aggressive tumor behaviors. Although CSCs are usually a small subpopulation of tumors ...