Now showing items 1-8 of 8
Ruxolitinib salvage therapy is effective for steroid-refractory graft-versus-host disease in children: a single-center experience
Background Despite the increasing performance of allogeneic hematopoietic cell transplantation over the last decades, graft-versus-host disease (GVHD) remains the main cause of morbidity and mortality. The efficacy of ...
Mutational landscape of severe combined immunodeficiency patients from Turkey
Severe combined immunodeficiency (SCID) has a diverse genetic aetiology, where a clinical phenotype, caused by single and/or multiple gene variants, can give rise to multiple presentations. The advent of next-generation ...
Hematopoietic stem cell transplantation in CD40 ligand deficiency: a single-center experience
Deficiency of the CD40L, expressed on the surface of T lymphocytes, is caused by mutations in the glycoproteinCD40L (CD154)gene. Resulting defective humoral and cellular responses cause a clinical presentation that includes ...
ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients
BackgroundDedicator of cytokinesis 8 (DOCK8) deficiency is the main cause of the autosomal recessive hyper-IgE syndrome (HIES). We previously reported the selective loss of group 3 innate lymphoid cell (ILC) number and ...
Use of low cell dose for unmanipulated donor lymphocyte for management of cytomegalovirus infection: a single-center experience
Although advancements have been made in monitoring and preventing viral infections in HSCT patients, CMV reactivation still remains a critical post-transplant complication. Adoptive cell therapy is an alternative to ...
Prognostic factors for survival in children who relapsed after allogeneic hematopoietic stem cell transplantation for acute leukemia
Background: Post-transplant relapse has a dismal prognosis in children with acute leukemia undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Data on risk factors, treatment options, and outcomes ...
Hematopoetic stem cell transplantation in CD40 ligand deficiency
Pearson syndrome in a patient transplanted for diamond-blackfan anemia