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Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response
Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent in the treatment of this malignant ...
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative diseases treatment
Protein homeostasis is a vital process for cell function and, therefore, disruption of the molecular mechanisms involved in this process, such as autophagy, may contribute to neurodegenerative diseases (NDs). Apart from ...
Targeted regulation of autophagy using nanoparticles: New insight into cancer therapy
Normal cells depend on autophagy to maintain cellular homeostasis by recycling damaged organelles and misfolded proteins and degrading toxic agents. Similar to apoptosis, targeting autophagy has been under attention in ...
Immunology meets bioengineering: Improving the effectiveness of glioblastoma immunotherapy
Glioblastoma (GBM) therapy has seen little change over the past two decades. Surgical excision followed by radiation and chemotherapy is the current gold standard treatment. Immunotherapy techniques have recently transformed ...