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Usnea filipendula induces apoptosis in human colon cancer cell lines
(Wolters Kluwer Medknow Publications, 2018)
Lichens are complex organisms living in a symbiotic relationship with fungi and algae have recently received special interest in cancer research. The cytotoxic activities of Usnea filipendula Stirt. lichen extract was ...
Synthesis, structures and anticancer potentials of platinum(II) saccharinate complexes of tertiary phosphines with phenyl and cyclohexyl groups targeting mitochondria and DNA
(Elsevier France-Editions Scientifiques Medicales Elsevier, 2018)
A series of new Pt(II) saccharinate complexes containing PR3 ligands (PPh3, PPh2Cy, PPhCy2 and PCy3) with progressive phenyl (Ph) replacement by cyclohexyl (Cy) were synthesized and structurally characterized by lR, NMR, ...
Characterization of imatinib-resistant K562 cell line displaying resistance mechanisms
(C M B Assoc, 2018)
Chronic myeloid leukemia (CML) is a hematopoietic malignancy characterized by the t(9; 22) and the related oncogene, BCR-ABL. Tyrosine kinase activity of fusion protein BCR-ABL is the main cause of CML. Even if imatinib ...
Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells
(Elsevier Ireland Ltd, 2018)
Cancer stem-like cells (CSCs) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, give rise to metastases and lead to disease relapse because of an acquired resistance to apoptosis. Especially, ...