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Effective and new potent drug combination: histone deacetylase and Wnt/beta-catenin pathway inhibitors in lung carcinoma cells
Lung cancer is the most commonly diagnosed cancer worldwide with a high mortality rate. In this study, the therapeutic effect of combination valproic acid and niclosamide was investigated on human lung cancer cell line. ...
Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells
(Elsevier Ireland Ltd, 2018)
Cancer stem-like cells (CSCs) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, give rise to metastases and lead to disease relapse because of an acquired resistance to apoptosis. Especially, ...