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Combination of histone deacetylase inhibitor with Cu(II) 5,5- diethylbarbiturate complex induces apoptosis in breast cancer stem cells: a promising novel approach

Erkisa, Merve; Aztopal, Nazlihan; Erturk, Elif; Ulukaya, Engin; Yilmaz, Veysel T; Ari, Ferda (2021)

Background: Cancer stem cells (CSC) are subpopulation within the tumor that acts a part in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes ...

Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells

Aztopal, Nazlihan; Erkisa Genel, Merve; Ertürk, Elif; Ulukaya, Engin; Tokullugil, Asuman Hatice; Ari, Ferda (Elsevier Ireland Ltd, 2018)

Cancer stem-like cells (CSCs) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, give rise to metastases and lead to disease relapse because of an acquired resistance to apoptosis. Especially, ...