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Effects of novel targeted anticancer drugs on cytotoxicity, apoptosis, angiogenesis, EMT, drug resistance and autophagic mechanism 

Aydinlik, S.; Uvez, A.; Armutak, E. I.; Dere, E.; Ulukaya, Engin (Oxford Univ Press, 2019)
Background: Metastatic coloncancer has asurvival rate less than %5 despite the use of effective chemotherapeutic regimen. Prognosticand predictiveimportance of EGFR is still contradictivein coloncancer. Tyrosine kinase ...
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A palladium(II)-saccharinate complex of terpyridine exerts higher anticancer potency and less toxicity than cisplatin in a mouse allograft model 

Cetin, Yuksel; Adiguzel, Zelal; Polat, Hivda U.; Akkoc, Tolga; Tas, Arzu; Cevatemre, Buse; Celik, Gokalp; Carikci, Baris; Yilmaz, Veysel T.; Ulukaya, Engin; Acilan, Ceyda (Lippincott Williams & Wilkins, 2017)
The main aim of this study is to assess the safety and antitumor efficacy of a palladium(II) (Pd)-saccharinate complex with terpyridine. To characterize the Pd(II) complex in vitro, its cytotoxicity was evaluated using a ...
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A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer 

Aztopal, Nazlihan; Karakas, Didem; Cevatemre, Buse; Ari, Ferda; Icsel, Ceyda; Daidone, Maria G.; Ulukaya, Engin (Pergamon-Elsevier Science Ltd, 2017)
Recent accumulating evidence has supported the notion that tumors have hierarchically organized heterogeneous cell populations and a small subpopulation of cells, termed cancer stem cells (CSCs), are responsible for tumor ...
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Cytotoxic effect of conyza canadensis (L.) cronquist on human lung cancer cell lines 

Ayaz, Fatma; Sarimahmut, Mehmet; Kucukboyaci, Nurgun; Ulukaya, Engin (Turkish Pharmacists Assoc, 2016)
Asteraceae family plants are receiving great attention because they have potential anticancer activity. Therefore, in this study, the cytotoxic effect of Conyza canadensis (L.) Cronquist (Asteraceae) were tested against ...
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The effect of NOTCH, IL-1 and LEPTIN (NILCO) inhibition in xenograft colorectal cancer 

Ozyurt, R.; Erkasap, N.; Ozkurt, M.; Erkasap, S.; Ulukaya, Engin; Dimas, K. (Wiley, 2019)
Questions: Studies in various cancer tissues have shown that Notch, IL-1 and leptin interaction (NILCO) play a role in the proliferation, migration and expression of proangogenic molecules. It has been suggested that ...
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Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: synthesis, characterization and anticancer activity 

Coskun, Demet; Erkisa, Merve; Ulukaya, Engin; Coskun, Mehmet Fatih; Ari, Ferda (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)
Cancer treatment still requires new compounds to be discovered. Chalcone and its derivatives exhibit anticancer potential in different cancer cells. A new series of benzofuran substituted chalcone derivatives was synthesized ...
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Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells 

Aydinlik, Seyma; Dere, Egemen; Ulukaya, Engin (Elsevier, 2019)
Background: It has been known epidermal growth factor receptor (EGFR) frequently overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a poor prognosis and inhibition frequently induces ...
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Bioassay-guided isolation of cytotoxic compounds from chrysophthalmum montanum (DC.) boiss 

Ayaz, Fatma; Kucukboyaci, Nurgun; Goren, Nezhun; Calis, Ihsan; Aydinlik, Seyma; Ulukaya, Engin; Duman, Hayri; Choudhary, Muhammad Iqbal (Pergamon-Elsevier Science Ltd, 2019)
Bioassay-guided isolation of the 80% methanol extract of the aerial parts of Chrysophthalmum montanum (DC.) Boiss. (Asteraceae) led to the isolation of four known guaianolide-type sesquiterpene lactones, 6 alpha-acetoxy-4 ...
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Protoflavone-chalcone hybrids exhibit enhanced antitumor action through modulating redox balance, depolarizing the mitochondrial membrane, and inhibiting ATR-dependent signaling 

Latif, Ahmed Dhahir; Jernei, Tamas; Podolski-Renic, Ana; Kuo, Ching-Ying; Vagvolgyi, Mate; Girst, Gabor; Zupko, Istvan; Develi, Elif Sedef; Ulukaya, Engin; Wang, Hui-Chun; Pesic, Milica; Csampai, Antal; Hunyadi, Attila (Mdpi, 2020)
Hybrid compounds combine fragments with complementary targets to achieve a common pharmacological goal. This approach represents an increasingly popular strategy for drug discovery. In this work, we aimed to design antitumor ...
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Epigenetic modulators combination with chemotherapy in breast cancer cells 

Ari, Ferda; Napieralski, Rudolf; Akgun, Oguzhan; Magdolen, Viktor; Ulukaya, Engin (Wiley, 2021)
Despite the concerning adverse effects on tumour development, epigenetic drugsare very promising in cancer treatment. The aim of this study was to compare the dif-ferential effects of standard chemotherapy regimens (FEC: ...
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Ari, Ferda (20)Cevatemre, Buse (11)Erkisa Genel, Merve (11)Erkisa, Merve (8)Erkısa Genel, Merve (8)Aztopal, Nazlıhan (7)Icsel, Ceyda (7)Karakaş Zeybek, Didem (7)Aydinlik, Seyma (6)... View MoreSubjectApoptosis (20)Cytotoxicity (16)Breast Cancer (8)Autophagy (5)Saccharinate (5)Lung Cancer (4)Anticancer Activity (3)Dna Damage (3)Doxorubicin (3)Epigenetic Modulators (3)... View MoreDate Issued2019 (14)2021 (14)2018 (12)2017 (9)2020 (8)2022 (8)2016 (1)2023 (1)Full Text StatusWith Full Text (62)Without Full Text (5)

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