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Chitosan: a versatile bio-platform for breast cancer theranostics
(ELSEVIER, 2022)
Breast cancer is considered one of the utmost neoplastic diseases globally, with a high death rate of patients. Over the last decades, many approaches have been studied to early diagnose and treat it, such as chemotherapy, ...
Transition Metal Dichalcogenides (TMDC)-Based Nanozymes for Biosensing and Therapeutic Applications
(MDPI, 2022)
Nanozymes, a type of nanomaterial with enzyme-like properties, are a promising alternative to natural enzymes. In particular, transition metal dichalcogenides (TMDCs, with the general formula MX2, where M represents a ...
Advances in understanding the role of P-gp in doxorubicin resistance: molecular pathways, therapeutic strategies, and prospects
(Elsevier, 2022)
P-glycoprotein (P-gp) is a drug efflux transporter that triggers doxorubicin (DOX) resistance. In this review, we highlight the molecular avenues regulating P-gp, such as Nrf2, HIF-1α, miRNAs, and long noncoding (lnc)RNAs, ...
EZH2 as a new therapeutic target in brain tumors: Molecular landscape, therapeutic targeting and future prospects
(Elsevier, 2022)
Brain tumors are responsible for high mortality and morbidity worldwide. The brain tumor treatment depends on identification of molecular pathways involved in progression and malignancy. Enhancer of zeste homolog 2 (EZH2) ...
Cellular targets and molecular activity mechanisms of bee venom in cancer: recent trends and developments
(2022)
Bee venom therapy is known as a traditional approach to curing many medical conditions such as arthritis, pain and rheumatism. Bee venom also provides promising potential for treating many cancers such as breast, lung, ...
The long and short non-coding RNAs modulating EZH2 signaling in cancer
(2022)
Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in encoding proteins. However, they participate in developmental and biological processes and their abnormal expression affects cancer ...
Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response
(2022)
Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent in the treatment of this malignant ...
Gold nanorods for drug and gene delivery: an overview of recent advancements
(2022)
Over the past few decades, gold nanomaterials have shown great promise in the field of nanotechnology, especially in medical and biological applications. They have become the most used nanomaterials in those fields due to ...
The importance of SNPs at miRNA binding sites as biomarkers of gastric and colorectal cancers: a systematic review
(2022)
Dysregulated mRNA-miRNA profiles might have the prospective to be used for early diagnosis of gastrointestinal cancers, estimating survival, and predicting response to treatment. Here, a novel biomarker based on miRNAs ...
Targeting autophagy, oxidative stress, and ER stress for neurodegenerative diseases treatment
(2022)
Protein homeostasis is a vital process for cell function and, therefore, disruption of the molecular mechanisms involved in this process, such as autophagy, may contribute to neurodegenerative diseases (NDs). Apart from ...