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Hydrogen sulphide and nitric oxide cooperate in cardioprotection against ischemia/reperfusion injury in isolated rat heart

Ustunova, Savas; Takir, Selcuk; Yilmazer, Nadim; Bulut, Huri; Altindirek, Didem; Ng, Ozden Hatirnaz; Tansel, Cihan Demirci; Dogan, Birsel Sonmez Uydes; Ozbek, Ugur; Ilkay Armutak, Elif; Gurevin, Ebru Gurel (NLM (Medline), 2020)

BACKGROUND/AIM: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H2S) and nitric oxide (NO) in ischemia/reperfusion (I/R) injury. MATERIALS AND METHODS: Rat hearts were ...

Assessment of the effect of endocrine abnormalities on biomacromolecules and lipids by FT-IR and biochemical assays as biomarker of metabolites in early Polycystic ovary syndrome women

Guleken, Zozan; Bulut, Huri; Bulut, Berk; Depciuch, Joanna (Elsevier, 2021)

Polycystic ovary syndrome (PCOS) is a common endocrinopathy associated with metabolic disturbances.Both in the development and improvement of the disease, the structure of phospholipids and proteinsin the blood serum plays ...

Assessment of structural protein expression by FTIR and biochemical assays as biomarkers of metabolites response in gastric and colon cancer

Guleken, Zozan; Bulut, Huri; Gültekin, Güldal İnal; Arikan, Soykan; Yaylim, Ilhan; Hakan, Mehmet Tolgahan; Sönmez, Dilara; Tarhan, Nevzat K.; Depciuch, Joanna (Elsevier B.V., 2021)

Colon and gastric cancers are the widespread benign types of cancers which are synchronous and metachronous neoplasms. In terms of the progression and progress of the disease, metabolic processes and differentiation in ...

Conserved amino acid residues that affect structural stability of candida boidinii formate dehydrogenase

Bulut, Huri; Yuksel, Busra; Gul, Mehmet; Eren, Meryem; Karatas, Ersin; Kara, Nazli; Yilmazer, Berin; Kocyigit, Abdurrahim; Labrou, Nikolaos E.; Bi̇nay, Barıs Is (Springer, 2021)

The NAD+-dependent formate dehydrogenase (FDH; EC 1.2.1.2) from Candida boidinii (CboFDH) has been extensively used in NAD(H)-dependent industrial biocatalysis as well as in the production of renewable fuels and chemicals ...

Effect of metal Ions on the activity of ten NAD-dependent formate dehydrogenases

Bulut, Huri; Valjakka, Jarkko; Yuksel, Busra; Yilmazer, Berin; Turunen, Ossi; Binay, Baris (2020)

NAD-dependent formate dehydrogenase (FDH) enzymes are frequently used in industrial and scientific applications. FDH is a reversible enzyme that reduces the NAD molecule to NADH and produces CO2 by oxidation of the formate ...

Spectrochemical and biochemical assay comparison study of the healing effect of the aloe vera and hypericum perforatum loaded nanofiber dressings on diabetic wound

Guleken, Zozan; Depciuch, Joanna; Ege, Hasan; Ilbay, Gul; Kalkandelen, Cevriye; Ozbeyli, Dilek; Bulut, Huri; Tarhan, Nevzat; Erdem Kuruca, Serap (Elsevier, 2021)

Diabetic wounds have a slow healing process and easy to be infected. In addition to current drug treatments, supportive approaches are needed for diabetic wound treatment. In this study, we aimed to load Aloe Vera (AV) and ...

Structural insights into the NAD+-dependent formate dehydrogenase mechanism revealed from the NADH complex and the formate NAD+ ternary complex of the Chaetomium thermophilum enzyme

Yilmazer, Berin; Isupov, Michail N.; De Rose, Simone Antonio; Bulut, Huri; Benninghoff, Jens C.; Bi̇nay, Baris Is; Littlechild, Jennifer Ann (Academic Press Inc., 2020)

The removal of carbon dioxide from the waste streams of industrial processes is a major challenge for creation of a sustainable circular economy. This makes the synthesis of formate from CO2 by NAD+ dependent formate ...

Serum kallistatin level is decreased in women with preeclampsia

Guralp, Onur; Tuten, Nevin; Gok, Koray; Hamzaoglu, Kubra; Bulut, Huri; Schild-Suhren, Meike; Malik, Eduard; Tuten, Abdullah (2021)

Objective To evaluate the serum levels of the serine proteinase inhibitor kallistatin in women with preeclampsia (PE). Methods The clinical and laboratory parameters of 55 consecutive women with early-onset PE (EOPE) and ...

Characterization of Covid-19 infected pregnant women sera using laboratory indexes, vibrational spectroscopy, and machine learning classifications

Guleken, Zozan; Jakubczyk, Paweł; Paja, W.; Krzysztof, Pancerz; Bulut, Huri; Öten, Esra; Depciuch, Joanna; Tarhan, Nevzat K. (Elsevier B.V., 2022)

Herein, we show differences in blood serum of asymptomatic and symptomatic pregnant women infected with COVID-19 and correlate them with laboratory indexes, ATR FTIR and multivariate machine learning methods. We collected ...

A low direct electrical signal attenuates oxidative stress and inflammation in septic rats

Ustunova, Savas; Haciosmanoglu, Ebru; Bulut, Huri; Elibol, Birsen; Kilic, Aysu; Hekimoglu, Rumeysa (PMC, 2021)

Electrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. ...