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Efficacy of stem cell therapy in ambulatory and nonambulatory children with Duchenne muscular dystrophy - Phase I-II

Dai, Alper; Baspinar, Osman; Yesilyurt, Ahmet; Sun Gungorurler, Eda; Aydemir, Cigdem Inci; Oztel, Olga Nehir; Karaoz, Erdal (Dove Medical Press Ltd, 2018)

Purpose: Duchenne muscular dystrophy (DMD) is an X-linked recessive pediatric disorder that ultimately leads to progressive muscle degeneration. It has been known that cell-based therapies were used to promote muscle ...

The effect of recombinant tyrosine hydroxylase expression on the neurogenic differentiation potency of mesenchymal stem cells

Turac, Gizem; Duruksu, Gokhan; Karaoz, Erdal (Korean Spinal Neurosurgery Soc, 2018)

Objective: Tyrosine hydroxylase (TH) is a rate-limiting enzyme in dopamine synthesis, making the enhancement of its activity a target for ensuring sufficient dopamine levels. Rat bone marrow mesenchymal stem cells (rBM-MSCs) ...

Effect of bone marrow and adipose tissue-derived mesenchymal stem cells on the natural course of corneal scarring after penetrating injury

Demirayak, Bengi; Yuksel, Nursen; Celik, Onur Sinan; Subasi, Cansu; Duruksu, Gokhan; Unal, Z. Seda; Yildiz, Demir Kursat; Karaoz, Erdal (Academic Press Ltd- Elsevier Science Ltd, 2016)

In the present study, we investigate and compare the efficacy of bone marrow- and adipose tissue-derived mesenchymal stem cell (MSCs) in corneal wound healing. A penetrating injury was created in the right corneas of Wistar ...

Wharton's jelly-derived mesenchymal stem cell transplantation in a patient with hypoxic-ischemic encephalopathy: a pilot study

Kabatas, Serdar; Civelek, Erdinc; Inci, Cigdem; Yalcinkaya, Ebru Yilmaz; Gunel, Guelsen; Kir, Guelay; Albayrak, Esra; Ozturk, Erek; Adas, Goekhan; Karaoz, Erdal (Sage Publications Inc, 2018)

Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) have been introduced as a possible therapy in hypoxic-ischemic encephalopathy (HIE). We report a 16-year-old boy who was treated with WJ-MSCs in the course of HIE ...

Sensitivity study for the key parameters in heterospheroid preparation with insulin-secreting beta-cells and mesenchymal stem cells

Bal, Tugba; Inceoglu, Yasemin; Karaoz, Erdal; Kizilel, Seda (Amer Chemical Soc, 2019)

The outcome of islet transplantation in clinics has been determined by the success of tissue engraftment. The strong immune attack that occurs upon transplantation of beta-cells plays a central role as this attack results ...

Search for novel plasma membrane proteins as potential biomarkers in human mesenchymal stem cells derived from dental pulp, adipose tissue, bone marrow, and hair follicle

Akpinar, Gurler; Karaosmanoglu Yoneten, Kubra; Kasap, Murat; Karaoz, Erdal (Springer Link, 2021)

One of the drawbacks preventing the use of mesenchymal stem cells (MSCs) in clinical practice is the heterogeneous nature of their cultures. MSC cultures are not homogeneously formed by the MSCs and may contain non-mesenchymal ...

Functional recovery after wharton's jelly-derived mesenchymal stem cell administration in a patient with traumatic brain injury: a pilot study

Kabatas, Serdar; Civelek, Erdinc; Sezen, Gulseli Berivan; Kaplan, Necati; Savrunlu, Eyup Can; Cetin, Ercan; Diren, Furkan; Karaoz, Erdal (TURKISH NEUROSURGICAL SOC, 2020)

AIM: To introduce a traumatic brain injury (TBI) patient who underwent stem cell transplantation (SCT) in order to minimize the remaining injury deficiencies. MATERIAL and METHODS: This study included a 29 years old ...

Can Wharton jelly derived or adipose tissue derived mesenchymal stem cell can be a treatment option for duchenne muscular dystrophy? answers as transcriptomic aspect

Sun Gungorurler, Eda; Karaoz, Erdal (2020)

Introduction: Mesenchymal stem cells (MSCs) are able to differentiate into several cell lineages including skeletal muscle. In addition to their differentiation capacities, they have the ability to transfer their content ...

Comparison of the effects of intratubal injection of adipose-derived mesenchymal stem cells in a rat sciatic nerve transection: an experimental study

Karakol, Percin; Kapı, Emin; Karaoz, Erdal; Tunik, Selcuk; Bozkurt, Mehmet (Wolters Kluwer, 2021)

This study was designed to evaluate the efficacy of epineural tubulization (ENT) with or without intratubal application of adipose-derived mesenchymal stem cells (ASCs) in the rat model of sciatic nerve transection. After ...

Generation of induced pluripotent stem cells from patients with multiple myeloma

Yilmaz Basaran, Irem; Karaoz, Erdal (gelenos, 2021)

Yamanaka and Takahashi made a discovery in the world of life science by transforming mouse somatic fibroblasts into pluripotent cells as a result of transferring 4 gene sets (Sox2-Oct4- Klf4&c-Myc) in 2006 (1). Since ...