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Structural studies and cytotoxic activity of a new dinuclear coordination compound of palladium(II)-2,2:6,2-terpyridine with rigid dianionic 1,2,4-triazole-3-sulfonate linker
(Wiley, 2018)
A new dinuclear coordination compound of palladium(II), [Pd-2(terpy)(2)(-tas-N-1,N-4)]SO(4)11H(2)O (1), was synthesized by tethering a doubly deprotonated 1,2,4-triazole-3-sulfonate (tas) linker generated in situ via ...
A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer
(Pergamon-Elsevier Science Ltd, 2017)
Recent accumulating evidence has supported the notion that tumors have hierarchically organized heterogeneous cell populations and a small subpopulation of cells, termed cancer stem cells (CSCs), are responsible for tumor ...
Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents
(Taylor & Francis Ltd, 2017)
Anticancer activity as an associated action for a series of dithiocarbamates of 9,10-anthracenedione was predicted using the PASS computer program and analysed with PharmaExpert software. The predicted cytotoxic activity ...
Cytotoxic effect of conyza canadensis (L.) cronquist on human lung cancer cell lines
(Turkish Pharmacists Assoc, 2016)
Asteraceae family plants are receiving great attention because they have potential anticancer activity. Therefore, in this study, the cytotoxic effect of Conyza canadensis (L.) Cronquist (Asteraceae) were tested against ...
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
(Academic Press Ltd- Elsevier Science Ltd, 2018)
Several natural products have been suggested as effective agents for the treatment of cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy hypothesis, it is worth investigating the ...
The MTT viability assay yields strikingly false-positive viabilities although the cells are killed by some plant extracts
(Tubitak Scientific & Technical Research Council Turkey, 2017)
The MTT assay is one of the often used cell viability/cytotoxicity assays. However, when the methanol extracts of plants are used to test their cytotoxic potential, interference may occur, resulting in false-positive ...
Chloroquine used in combination with chemotherapy synergistically suppresses growth and angiogenesis in vitro and in vivo
(Int Inst Anticancer Research, 2018)
Background: The inhibition of autophagy using pharmacological inhibitors such as chloroquine may be an effective strategy to overcome chemotherapy or resistance to anti-angiogenic therapy. Materials and Methods: The cytotoxic ...
Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line
(Elsevier Science Bv, 2017)
Background: The outcome of triple negative breast cancer is still poor and requires improvement with better therapy options. Autophagy has recently been shown to play a role in anticancer drug resistance. Therefore, we ...
Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines
(Pergamon-Elsevier Science Ltd, 2017)
Metal-based chemotherapeutics such as cisplatin are widely used treatment of lung cancer which is the major cause of cancer-related mortality worldwide. Recent studies demonstrated that novel metal-based compounds have ...
