Search

Now showing items 1-7 of 7

A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer

Cevatemre, Buse; Erkısa Genel, Merve; Aztopal, Nazlıhan; Karakaş Zeybek, Didem; Alper, Pınar; Tsimplouli, Chrisiida; Sereti, Evangelia; Dimas, Konstantinos; Armutak, Elif I. İkitimur; Gürevin, Ebru Gürel; Üvez, Ayça; Mori, Mattia; Berardozzi, Simone; Ingallina, Cinzia; D'Acquarica, Ilaria; Botta, Bruno; Özpolat, Bülent; Ulukaya, Engin (Academic Press Ltd- Elsevier Science Ltd, 2018)

Several natural products have been suggested as effective agents for the treatment of cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy hypothesis, it is worth investigating the ...

Combination of histone deacetylase inhibitor with Cu(II) 5,5- diethylbarbiturate complex induces apoptosis in breast cancer stem cells: a promising novel approach

Erkısa Genel, Merve; Aztopal, Nazlıhan; Ertürk, Elif; Ulukaya, Engin; Yılmaz, Veysel Turan; Ari, Ferda (2021)

Background: Cancer stem cells (CSC) are subpopulation within the tumor that acts a part in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes ...

Key actors in cancer therapy: epigenetic modifiers

Akar, Remzi Okan; Selvi, Selin; Ulukaya, Engin; Aztopal, Nazlıhan (Tubitak Scientific & Technical Research Council Turkey, 2019)

Epigenetic reprogramming plays a crucial role in the tumorigenicity and maintenance of tumor-specific gene expression that especially occurs through DNA methylation and/or histone modifications. It has well-defined mechanisms. ...

Dual inhibition of Wnt/beta-catenin signaling and histone deacetylation as a new strategy to eliminate breast cancer stem cells by augmentation of apoptosis

Aztopal, Nazlıhan; Erkısa Genel, Merve; Ari, F.; Dere, E.; Ulukaya, Engin (Wiley, 2018)

…

Toxicity assessment of Hypericum olympicum subsp. olympicum L. on human lymphocytes and breast cancer cell lines

Balıkçı, Necmiye; Sarımahmut, Mehmet; Arı, Ferda; Aztopal, Nazlıhan; Özel, Mustafa Zafer; Ulukaya, Engin; Çelikler, Serap (Univ South Bohemia, 2020)

There is a limited number of studies about the constituents of Hypericum olympicum subsp. olympicum and its genotoxic and cytotoxic potency. We examined the possible antigenotoxic/genotoxic properties of methanolic extract ...

A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex

Erkısa Genel, Merve; Aydınlık, Şeyma; Cevatemre, Buse; Aztopal, Nazlıhan; Akar, Remzi Okan; Çelikler, Serap; Yılmaz, Veysel Turan; Ari, Ferda; Ulukaya, Engin (Elsevier B.V., 2020)

Autophagy is a catabolic process for cells that can provide energy sources and allows cancer cells to evade cell death. Therefore, studies on the combination of autophagy inhibitors with drugs are increasing as a new ...

Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells

Aztopal, Nazlıhan; Erkısa Genel, Merve; Ertürk, Elif; Ulukaya, Engin; Tokullugil, Asuman Hatice; Arı, Ferda (Elsevier Ireland Ltd, 2018)

Cancer stem-like cells (CSCs) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, give rise to metastases and lead to disease relapse because of an acquired resistance to apoptosis. Especially, ...