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Novel 5-fluorouracil complexes of Zn(II) with pyridine-based ligands as potential anticancer agents
(2022)
A series of novel Zn(II) complexes of 5-fluorouracilate (5-FU), namely [Zn(5-FU)2(bpy)] (1), [Zn(5-FU)2(phen)] (2), [Zn(5-FU)2(dpya)]·H2O (3), [Zn(5-FU)2(bpyma)]·2H2O (4) and [Zn(5-FU)2(terpy)]·H2O (5), were synthesized ...
Differential of cholangiocarcinoma disease using Raman spectroscopy combined with multivariate analysis
(2022)
Cholangiocarcinoma (CCA) is a type of cancer, which 5-year survival is lower than 20 %, and which is detected mostly in advanced stage of the disease. Unfortunately, there are no diagnostic tools, which could show changes ...
Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy
(2022)
A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and ...
Evidence for heterogeneity in response to treatment in mammary tumors of dogs as happens in humans
(NCI CPTAC Assay Portal, 2022)
Tumors are formed by various clones developed over a long time. This gives rise to a heterogeneous nature. This heterogeneity is the hardest challenge in the treatment of cancers because it is the main reason for drug ...
DNA damage response inhibitors in cholangiocarcinoma: current progress and perspectives
(PubMed, 2022)
Cholangiocarcinoma (CCA) is a poorly treatable type of cancer and its incidence is dramatically increasing. The lack of understanding of the biology of this tumor has slowed down the identification of novel targets and the ...
Identification of key genes and pathways for cholangiocarcinoma using an integrated bioinformatics analysis
(Kare Publishing, 2022)
Objectives: The scope of this study was to identify potential genes as a promising biomarker in diagnosing cholangio-carcinoma (CCA) or differentiating the subtypes of CCA. In this study, we used Gene Expression Omnibus ...
The improved killing of both androgen-dependent and independent prostate cancer cells by etoposide loaded SPIONs coupled with NIR irradiation
(Royal Society of Chemistry, 2022)
Etoposide (Eto) is a toxic drug that shows promise in treating prostate cancer (PCa) but confers significant side effects, and has poor solubility and bioavailability. Nanoparticles are quite successful in overcoming such ...
Synthesis, DNA binding and cytotoxic activity of newcopper(II) complexes of trisubstituted imidazoles
(Springer, 2022)
This study was aimed to synthesize and characterize two new copper(II) complexes, [Cu(phen)(Br-impi)]2+ (1) and [Cu(phen)(M-impi)]2+ (2) (where phen is 1,10-phenanthroline; Br-impi is 2-(2-(4-bromophenyl)-4- (pyridin-2-y ...