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Palladium (II) complex enhances ROS-dependent apoptotic effects via autophagy inhibition and disruption of multiple signaling pathways in colorectal cancer cells

Aydinlik, Seyma; Erkisa Genel, Merve; Ari, Ferda; Celikler, Serap; Ulukaya, Engin (2021)

Background: Inhibition of autophagy is reported to be a therapeutically effective strategy in overcoming the resistance that is a deadly outcome in cancer. One of the most common reasons for chemo-resistance to treatment ...

Palladium (II) complex and thalidomide intercept angiogenic signaling via targeting FAK/Src and Erk/Akt/PLC gamma dependent autophagy pathways in human umbilical vein endothelial cells

Aydinlik, Seyma; Uvez, Ayca; Kiyan, Hulya Tuba; Gurel-Gurevin, Ebru; Yilmaz, Veysel Turan; Ulukaya, Engin (Elsevier, 2021)

The current study assessed the effects of the thalidomide and palladium (II) saccharinate complex of terpyridine on the suppression of angiogenesis-mediated cell proliferation. The viability was assessed after treatment ...