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The effect of umbilical cord-derived mesenchymal stem cell transplantation in a patient with cerebral palsy: a case report

Okur, Sibel Caglar; Erdogan, Sinan; Subasi Demir, Cansu; Gunel, Gulsen; Karaoz, Erdal (Korean Soc Stem Cell Research, 2018)

Background: Cerebral Palsy (CP) is the most common motor disability reason of childhood that occurs secondarily to non-progressive damage in the brain whose development is still ongoing. Methods: 6-year-old dystonic-spastic ...

Efficacy of stem cell therapy in ambulatory and nonambulatory children with Duchenne muscular dystrophy - Phase I-II

Dai, Alper; Baspinar, Osman; Yesilyurt, Ahmet; Sun Gungorurler, Eda; Aydemir, Cigdem Inci; Oztel, Olga Nehir; Karaoz, Erdal (Dove Medical Press Ltd, 2018)

Purpose: Duchenne muscular dystrophy (DMD) is an X-linked recessive pediatric disorder that ultimately leads to progressive muscle degeneration. It has been known that cell-based therapies were used to promote muscle ...

The effect of recombinant tyrosine hydroxylase expression on the neurogenic differentiation potency of mesenchymal stem cells

Turac, Gizem; Duruksu, Gokhan; Karaoz, Erdal (Korean Spinal Neurosurgery Soc, 2018)

Objective: Tyrosine hydroxylase (TH) is a rate-limiting enzyme in dopamine synthesis, making the enhancement of its activity a target for ensuring sufficient dopamine levels. Rat bone marrow mesenchymal stem cells (rBM-MSCs) ...

Wharton's jelly-derived mesenchymal stem cell transplantation in a patient with hypoxic-ischemic encephalopathy: a pilot study

Kabatas, Serdar; Civelek, Erdinc; Inci, Cigdem; Yalcinkaya, Ebru Yilmaz; Gunel, Guelsen; Kir, Guelay; Albayrak, Esra; Ozturk, Erek; Adas, Goekhan; Karaoz, Erdal (Sage Publications Inc, 2018)

Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) have been introduced as a possible therapy in hypoxic-ischemic encephalopathy (HIE). We report a 16-year-old boy who was treated with WJ-MSCs in the course of HIE ...

Neuronal regeneration in injured rat spinal cord after human dental pulp derived neural crest stem cell transplantation

Kabatas, S.; Demir, C. S.; Civelek, E.; Yilmaz, I; Kircelli, A.; Yilmaz, C.; Karaoz, Erdal (Comenius Univ, 2018)

OBJECTIVE: This study aimed to analyze the effect of human Dental Pulp-Neural Crest Stem Cells (hDP-NCSCs) delivery on lesion site after spinal cord injury (SCI), and to observe the functional recovery after transplantation. ...