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Quantification of DNA damage products by gas chromatography tandem mass spectrometry in lung cell lines and prevention effect of thyme antioxidants on oxidative induced DNA damage

Aybastier, Onder; Dawbaa, Sam; Demir, Cevdet; Akgun, Oguzhan; Ulukaya, Engin; Ari, Ferda (Elsevier Science Bv, 2018)

Lung cancer has a high treatment cost and poor prognosis in comparison to other types of cancers. This work was involved in studying oxidative DNA base damage inhibition. Accordingly, standard carvacrol, thymol, thymoquinone ...

Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells

Aztopal, Nazlihan; Erkisa Genel, Merve; Ertürk, Elif; Ulukaya, Engin; Tokullugil, Asuman Hatice; Ari, Ferda (Elsevier Ireland Ltd, 2018)

Cancer stem-like cells (CSCs) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, give rise to metastases and lead to disease relapse because of an acquired resistance to apoptosis. Especially, ...