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Naftakinon türevli yeni sentez bileşiklerin kanser hücre hatları üzerine etkisinin incelenmesi

Akar, Remzi Okan (İstinye Üniversitesi / Sağlık Bilimleri Enstitüsü, 2020)

Prostat kanseri dünyada ikinci, İskandinavya da dahil gelişmiş ülkelerde ise en sık rastlanan birinci kanser türüdür. Hormon ve/veya kemoterapi tedavisi sonrası hücrelerde meydana gelen direnç kanser kaynaklı ölümlerin ...

Etoposide loaded SPION-PNIPAM nanoparticles improve the in vitro therapeutic outcome on metastatic prostate cancer cells via enhanced apoptosis

Erkisa Genel, Merve; Ari, Ferda; Ulku, Irem; Khodadust, Rouhollah; Yar, Yasemin; Acar, Havva Yagci; Ulukaya, Engin (2020)

Prostate cancer is among the leading causes of death worldwide because its metastatic form is a deadly disease. Therefore, the development of new chemotherapeutics is of immense importance. Nanoparticle technology seems ...

Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation

Karakaş Zeybek, Didem; Cevatemre, Buse; Oral, Arzu Y.; Yılmaz, Veysel T.; Ulukaya, Engin (Bentham Science Publ Ltd, 2019)

Background: Prostate cancer is one of the most common cancer types and it is the sixth leading cause of cancer-related death in men worldwide. Even though novel treatment modalities have been developed, it still a ...

Mechanisms of abemaciclib, a CDK4/6 inhibitor, induced apoptotic cell death in prostate cancer cells in vitro

Güney Eskiler, Gamze; Deveci Özkan, Asuman; Hacıefendi, Ayten; Bilir, Cemil (Elsevier, 2022)

The therapeutic effects of abemaciclib (ABE), an inhibitor of cyclin- dependent kinases (CDK) 4/6, on the proliferation of two types of prostate cancer (PC) cells were revealed. In this study, in vitro cytotoxic and apoptotic ...