Search

Now showing items 1-6 of 6

Soloxolone methyl, as a 18βH-glycyrrhetinic acid derivate, may result in endoplasmic reticulum stress to induce apoptosis in breast cancer cells

Alper, Pinar; Salomatina, Oksana V.; Salakhutdinov, Nariman F.; Ulukaya, Engin; Ari, Ferda (Elsevier Ltd, 2021)

Being one of the leading causes of cancer death among women, various chemotherapeutic agents isolated from natural compounds are used in breast cancer treatment and consequently studies to develop new drugs still continue. ...

Preparation and characterization of palladium derivate-loaded micelle formulation in vitro as an innovative therapy option against non-small cell lung cancer cells

Erkisa, Merve; Ari, Ferda; Buyukkoroglu, Gulay; Senel, Bedriye; Yilmaz, Veysel Turan; Ulukaya, Engin (WILEY, 2021)

Nanoparticles have been used in cancer treatments to target tumor and reduce side effects. In this study, we aimed to increase the effectiveness of palladium(II) complex [PdCl(terpy)](sac)·2H2O, which previously showed ...

Palladium (II) complex enhances ROS-dependent apoptotic effects via autophagy inhibition and disruption of multiple signaling pathways in colorectal cancer cells

Aydinlik, Seyma; Erkisa Genel, Merve; Ari, Ferda; Celikler, Serap; Ulukaya, Engin (2021)

Background: Inhibition of autophagy is reported to be a therapeutically effective strategy in overcoming the resistance that is a deadly outcome in cancer. One of the most common reasons for chemo-resistance to treatment ...

Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis

Ozturk, Sule; Erkisa Genel, Merve; Oran, Oran; Ulukaya, Engin; Celikler, Serap; Ari, Ferda (Taylor and Francis Ltd, 2021)

Successful cancer treatment still requires new complexes or compounds from natural sources. Therefore, we investigated anti-growth/apoptotic effects of methanol extracts of the lichen species (Xanthoparmelia somloensis ...

Anticancer potential of albumin bound wnt/beta-catenin pathway inhibitor niclosamide in breast cancer cells

Ari, Ferda; Erkisa, Merve; Pekel, Gonca; Erturk, Elif; Buyukkoroglu, Gulay; Ulukaya, Engin (WILEY, 2021)

Albumin-based nanoparticle transport systems (nab-technology) are a new strategy in cancer treatment and we aimed to increase the effectiveness of Niclosamide using this technology. Niclosamide was bound with bovine serum ...

Combination of histone deacetylase inhibitor with Cu(II) 5,5- diethylbarbiturate complex induces apoptosis in breast cancer stem cells: a promising novel approach

Erkısa Genel, Merve; Aztopal, Nazlıhan; Ertürk, Elif; Ulukaya, Engin; Yılmaz, Veysel Turan; Ari, Ferda (2021)

Background: Cancer stem cells (CSC) are subpopulation within the tumor that acts a part in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes ...