Makale Koleksiyonu
Recent Submissions
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A scoping systematic assessment for post-marketing abuse drug withdrawal
(OXFORD UNIV PRESS, 2022)Objectives The aim of this study was to identify the post-marketing withdrawal of medicines due to their adverse drug reactions (ADRs)-related abuse effects and to examine the types of evidence, mechanisms and patterns for ... -
The long view on COVID-19 theranostics and oral antivirals: living with endemic disease and lessons from molnupiravir
(Atypon, 2022)The long view on living with COVID-19 as an endemic disease calls for expanding the planetary health inter-vention toolbox. We will need a battery of vaccines, small molecule oral antiviral drugs, and biomarkers toforecast ... -
Comparative Studies on Essential Oil and Phenolic Content with In Vitro Antioxidant, Anticholinesterase, Antimicrobial Activities of Achillea biebersteinii Afan. and A. millefolium subsp. millefolium Afan. L. Growing in Eastern Turkey
(2022)The potential applications of Achillea species in various industries have encouraged the examination of their phytochemical components along with their biological potential. In the present study, phenolic contents and ... -
Phytochemical screening and biological evaluation of Salvia hydrangea Dc. ex Benth. growing in eastern Anatolia
(Elsevier B.V., 2022)Salvia species have lately gained significant interest as a result of their suitable utilization in various industries. In the current study, S. hydrangea, one of the most consumed sages in the eastern region of Turkey, ... -
Phytochemical composition and pharmacological activities of Teucrium polium L. Collected from eastern Turkey
(TUBITAK, 2022)Teucrium species that belong to the family Lamiaceae have been traditionally used for their medicinal properties. T. polium is one the most widespread members of the genus for its use in the treatment of several diseases. ... -
Antioxidant and antimicrobial activities of various extracts from Stachys cretica subsp. bulgarica Rech.f., Stachys byzantina K. Koch and Stachys thirkei K. Koch
(Istanbul University Press, 2021)Background and Aims: Stachys L. species, which are members of the Lamiaceae family, have long been applied for their therapeutic benefits especially to cure cough, infection, genital tumors, ulcers, inflammatory illnesses, ... -
Voluntary oral methamphetamine increases memory deficits and contextual sensitization during abstinence associated with decreased PKMζ and increased κOR in the hippocampus of female mice
(Sage Journals, 2021)Background: Female populations exhibit vulnerabilities to psychostimulant addiction, as well as cognitive dysfunction following bouts of abuse. Aims: The goal for this study was to advance our understanding of the ... -
Antibacterial and antifungal activities of isoquinoline alkaloids of the Papaveraceae and Fumariaceae families and their implications in structure–activity relationships
(Elsevier B.V., 2021)Historically, plants with a wide range of natural products they possess have long served as important sources of therapeutical agents. Unfortunately, progress in the construction of synthetic chemical libraries shifted the ... -
Thanatechnology and the living dead: new concepts in digital transformation and human-computer interaction
(MARY ANN LIEBERT, 2021)In a digital society, shall we be the authors of our own experience, not only during our lifetime but also after we die? We ask this question because dying and bereavement have become even harder, and much less private, ... -
Quality of turmeric powder in herbal stores: pharmacognostical investigations on turmeric powders obtained from herbal stores in Istanbul, Turkey
(ISTANBUL UNIV, 2021)Background and Aims: Curcuma longa L., known as Turmeric, has been traditionally used in Asian culture since ancient times to treat several disorders. With the increase in studies on turmeric and its major compounds, it ... -
Butyrylcholinesterase-inhibiting natural coumarin molecules as potential leads
(Elsevier Ltd, 2021)Seventeen natural coumarin derivatives; badrakemin (1), 14′-acetoxybadrakemin (2), badrakemone (3), 14′-acetoxybadrakemone (4), colladonin (5), colladonin acetate (6), 14′-acetoxycolladonin (7), karatavicinol (8), deltoin ... -
The hCOMET project: international database comparison of results with the comet assay in human biomonitoring. baseline frequency of DNA damage and effect of main confounders
(Elsevier B.V., 2021)The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those ... -
Agomelatine is superior to melatonin in pain suppression: an experimental study
(AVES, 2020)Objective: Agomelatine is a synthetic analog of melatonin with selective agonist action on melatonin MT1 and MT2 receptors and antagonistic effect on serotonin 5HT2c receptors. Similar to melatonin, it also has antinociceptive ... -
Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity
(ACG Publications, 2020)Herein, a facile procedure for microwave synthesis and NMR characterization of phenothiazine derivatives 10-(3-hydroxypropyl)-2-(methylsulphanyl)-10H-phenothiazine (3) (25% yield) and 1-[3-(2-methylsulfanyl-10H-phenothia ... -
Biomonitoring of heavy metal(oid)s in the residents of abandoned mining district in northern cyprus
(Springer, 2021)Abstract Several heavy metal(oid)s are known mutagens and/or carcinogens. Exposure to these elements can lead to the development of malignancies. Gemikonagi, which is in the western part of Cyprus, was the hometown of ... -
Cross referencing 2D-LC determination of intact gliptins in urine
(2020)Dipeptidyl peptidase-4 inhibitors, so-called gliptins, constitute a fairly novel class of oral hypoglycemic agents. The development and validation of an automated online SPE-LC-UV method to determine intact sitagliptin, ... -
Quinoline-based promising anticancer and antibacterial agents, and some metabolic enzyme inhibitors
(Wiley-VCH Verlag, 2020)A series of substituted quinolines was screened for their antiproliferative, cytotoxic, antibacterial activities, DNA/protein binding affinity, and anticholinergic properties by using the 3-(4,5-dimethylthiazol-2-yl)-2,5 ... -
Design, synthesis and cytotoxic activity of spiro(oxindole-3-3'-pyrrolidine) derivatives
(Bentham Science Publ Ltd, 2018)Background: Spiro[pyrrolidine-3,3'-oxindole] compounds are reported to be highly bioactive natural and synthetic products. Initially, spirooxindole alkaloids were isolated from plants of the Apocynaceae and Rubiaceae ... -
Evaluation of avocado (Persea americana Mill.) leaves in terms of public health
(Marmara Univ, 2018)Persea americana Mill. (Lauraceae) originated in Central and Southern of South America, is an evergreen tree. The tree is commonly known as avocado. Avocado is cultivated in all tropical and subtropical regions in the ... -
Determination of antibiotic resistance and pulsed-field gel electrophoresis profiles for the extended-spectrum beta-lactamase producing Escherichia coli
(Ahvaz Jundishapur Univ Med Sci, 2018)Background: Production of extended-spectrum beta-lactamase (ESBL) is one of the antibiotic resistance strategies in the bacteria. Extended spectrum beta-lactamase producing Escherichia coli (E. coli) infections alarmingly ...
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