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Hydrogen sulphide and nitric oxide cooperate in cardioprotection against ischemia/reperfusion injury in isolated rat heart

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Date

2020

Author

Ustunova, Savas
Takir, Selcuk
Yilmazer, Nadim
Bulut, Huri
Altindirek, Didem
Ng, Ozden Hatirnaz
Tansel, Cihan Demirci
Dogan, Birsel Sonmez Uydes
Ozbek, Ugur
Ilkay Armutak, Elif
Gurevin, Ebru Gurel

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Citation

Ustunova, S., Takir, S., Yilmazer, N., Bulut, H., Altindirek, D., Ng, O. H., ... & Gurevin, E. G. (2020). Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart. In Vivo, 34(5), 2507-2516.

Abstract

BACKGROUND/AIM: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H2S) and nitric oxide (NO) in ischemia/reperfusion (I/R) injury. MATERIALS AND METHODS: Rat hearts were studied with the Langendorff technique using the H2S donor sodium hydrosulfide (NaHS, 40 μM) and the cystathionine gamma-lyase (CTH or CSE) inhibitor DL-propargylglycine (PAG, 1 mM). NO synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME, 30 mg/kg, 7 days) was administered before the isolation. The hearts were homogenized for biochemical and molecular analysis. RESULTS: NaHS reversed I/R-induced cardiac performance impairment, increased tissue nitric oxide production and decreased tissue markers for cardiac injury, while L-NAME inhibited these effects. The expression of CTH was increased with PAG, which was suppressed by L-NAME. CONCLUSION: H2S and NO increase each other's production suggesting their interaction and cooperation in cardioprotection against I/R injury.

Source

In vivo (Athens, Greece)

Volume

34

Issue

1

URI

https://www.doi.org/10.21873/invivo.12067
https://hdl.handle.net/20.500.12713/1009

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  • Scopus İndeksli Yayınlar Koleksiyonu [707]
  • WoS İndeksli Yayınlar Koleksiyonu [774]



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