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dc.contributor.authorUstunova, Savas
dc.contributor.authorTakir, Selcuk
dc.contributor.authorYilmazer, Nadim
dc.contributor.authorBulut, Huri
dc.contributor.authorAltindirek, Didem
dc.contributor.authorNg, Ozden Hatirnaz
dc.contributor.authorTansel, Cihan Demirci
dc.contributor.authorDogan, Birsel Sonmez Uydes
dc.contributor.authorOzbek, Ugur
dc.contributor.authorIlkay Armutak, Elif
dc.contributor.authorGurevin, Ebru Gurel
dc.date.accessioned2020-09-10T12:43:31Z
dc.date.available2020-09-10T12:43:31Z
dc.date.issued2020en_US
dc.identifier.citationUstunova, S., Takir, S., Yilmazer, N., Bulut, H., Altindirek, D., Ng, O. H., ... & Gurevin, E. G. (2020). Hydrogen Sulphide and Nitric Oxide Cooperate in Cardioprotection Against Ischemia/Reperfusion Injury in Isolated Rat Heart. In Vivo, 34(5), 2507-2516.en_US
dc.identifier.issn1791-7549
dc.identifier.urihttps://www.doi.org/10.21873/invivo.12067
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1009
dc.descriptionPubmed: 32871779en_US
dc.description.abstractBACKGROUND/AIM: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H2S) and nitric oxide (NO) in ischemia/reperfusion (I/R) injury. MATERIALS AND METHODS: Rat hearts were studied with the Langendorff technique using the H2S donor sodium hydrosulfide (NaHS, 40 μM) and the cystathionine gamma-lyase (CTH or CSE) inhibitor DL-propargylglycine (PAG, 1 mM). NO synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME, 30 mg/kg, 7 days) was administered before the isolation. The hearts were homogenized for biochemical and molecular analysis. RESULTS: NaHS reversed I/R-induced cardiac performance impairment, increased tissue nitric oxide production and decreased tissue markers for cardiac injury, while L-NAME inhibited these effects. The expression of CTH was increased with PAG, which was suppressed by L-NAME. CONCLUSION: H2S and NO increase each other's production suggesting their interaction and cooperation in cardioprotection against I/R injury.en_US
dc.language.isoengen_US
dc.publisherNLM (Medline)en_US
dc.relation.isversionof10.21873/invivo.12067en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHydrogen Sulfideen_US
dc.subjectIschemia / Reperfusion Injuryen_US
dc.subjectIsolated Hearten_US
dc.subjectNitric Oxideen_US
dc.subjectOxidative Damageen_US
dc.titleHydrogen sulphide and nitric oxide cooperate in cardioprotection against ischemia/reperfusion injury in isolated rat hearten_US
dc.typearticleen_US
dc.contributor.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.contributor.authorID0000-0003-2706-9625en_US
dc.contributor.institutionauthorBulut, Huri
dc.identifier.volume34en_US
dc.identifier.issue1en_US
dc.identifier.startpage2507en_US
dc.identifier.endpage2516en_US
dc.relation.journalIn vivo (Athens, Greece)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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