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dc.contributor.authorOzmen, Mehmet Mahir
dc.contributor.authorGundogdu, Emre
dc.contributor.authorGuldogan, Cem Emir
dc.contributor.authorOzmen, Fusun
dc.date.accessioned2020-09-14T07:43:34Z
dc.date.available2020-09-14T07:43:34Z
dc.date.issued2021
dc.identifier.citationOzmen, M. M., Gundogdu, E., Guldogan, C. E., & Ozmen, F. (2020). The Effect of Bariatric Surgery on Exocrine Pancreatic Function. Obesity Surgery, 1-8.en_US
dc.identifier.issn0960-8923
dc.identifier.urihttps://doi.org/10.1007/s11695-020-04950-1
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1017
dc.descriptionPubmed: 32885359en_US
dc.description.abstractAbstract Introduction: After bariatric surgery (BS), patients might suffer from nutrient maldigestion, malabsorption, and vitamin deficiencies. In this study, our aim was to assess pancreatic functions after BS using fecal elastase-1 assay (FE-1). Material and Methods: Sixty patients (21M) undergoing BS and 20 (6M) healthy controls were included into the study. Stool samples were collected 1 year after surgery. Ten patients from one anastomosis gastric bypass (OAGB) and single anastomosis duodenal switch (SADS) groups with the lowest value of FE-1 and GIQLI scores were given pancreatic enzyme replacement therapy (PERT). After PERT, FE-1, excess weight loss (EWL), BMI, GIQLI scores, and vitamin D levels were measured. Results: Vitamin D levels were detected as 19.04 (9–46.5) pg/ml, 15.1 (8.4–23.6) pg/ml, 17.8 (5–30) pg/ml, and 21.79 (11–40.3) pg/ml after sleeve gastrectomy (SG), OAGB, SADS, and control groups, respectively (p = 0.04). GIQLI scores in the first year were found to have increased in all patients (p = 0.02). FE-1 levels were found as 642.35 (566.3–711.4) μg/g, 378.52 (183.5–561.1) μg/g, 458.88 (252.5–593, 5) μg/g, and 518.2 (351.6–691) μg/g for the SG, OAGB, SADS, and control groups, respectively. There was a strong inverse correlation between EWL and FE-1 levels at the end of the first year (Spearman’s rho = − 0.688, p = 0.003). After having performed PERT for patients with the lowest FE-1 levels, the levels increased to 683.39 (615.5–720) μg/g in the OAGB and 691.5 (643.1–720) μg/g in the SADS groups (p = 0.011). Conclusion: FE-1 measurements demonstrated that many patients suffer from malabsorption after OAGB or SADS, whereas functions remain normal after SG. PERT corrects pancreatic functions without affecting weight loss and also contributes to the normal serum level of vitamin D.en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.relation.isversionof10.1007/s11695-020-04950-1en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBariatric Surgeryen_US
dc.subjectExocrine Pancreatic Functionen_US
dc.subjectExocrine Pancreatic Insufficiencyen_US
dc.subjectFecal Elastase-1en_US
dc.subjectPancreatic Enzyme Replacement Therapyen_US
dc.titleThe effect of bariatric surgery on exocrine pancreatic functionen_US
dc.typearticleen_US
dc.contributor.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.contributor.authorID0000-0003-0649-0111en_US
dc.contributor.institutionauthorOzmen, Mehmet Mahir
dc.contributor.institutionauthorGundogdu, Emre
dc.contributor.institutionauthorGuldogan, Cem Emir
dc.relation.journalObesity Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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