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A new inflammatory marker: elevated eosinophil-tolymphocyte ratio associated with presence and severity of isolated coronary artery ectasia

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Date

2020

Author

Yilmaz, Mucahid
Kayancicek, Hidayet
Korkmaz, Hasan
Gozel, Nevzat
Bilen, Mehmet Nail
Secen, Ozlem
Oner, Pinar
Uku, Okkes
Demirkiran, Suat
Cekici, Yusuf
Eroglu, Orkun

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Citation

Yilmaz, M., Kayançiçek, H., Korkmaz, H., Gözel, N., Bilen, M. N., Seçen, Ö., Öner, P., Uku, Ö., Demirkiran, S., Çekici, Y., Eroğlu, O., & Ertuğrul, K. (2020). A new inflammatory marker: elevated eosinophil-tolymphocyte ratio associated with presence and severity of isolated coronary artery ectasia. Cardiovascular journal of Africa, 31, 1–9. Advance online publication. https://doi.org/10.5830/CVJA-2019-049

Abstract

Objectives: The pathophysiology of isolated coronary artery ectasia (CAE) involves atherosclerosis and inflammation. Eosinophils and lymphocytes have been found to play a significant role in inflammation, atherosclerosis and endothelial dysfunction. Many studies have explored the relationship between isolated CAE and systemic inflammation. However, there are no data regarding the relationship between eosinophil-to-lymphocyte ratio (ELR) and isolated CAE. Therefore, this study analysed the relationship between ELR and isolated CAE. Methods: All patients who underwent coronary angiography between January 2009 and June 2018 were investigated retrospectively. Of 16 240 patients, 232 patients with isolated CAE (141 males) and 247 age- and gender-matched control subjects (130 males) with normal coronary angiography (NCA) were enrolled in this study. Baseline demographic and laboratory data were obtained from the hospital database. The severity of isolated CAE was determined according to the Markis classification, vessel count and diffuseness of ectasia. Results: Patients with angiographic isolated CAE had significantly elevated white blood cell (WBC) and eosinophil counts and ELR values compared to patients with NCA [8.11 ± 1.75 vs 7.49 ± 1.80 × 109 cells/l, p < 0.0001; 0.22 (0.13-0.32) vs 0.19 (0.12-0.28) × 109 cells/l, p = 0.02; 0.11 (0.06-0.17) vs 0.08 (0.05-0.12), p < 0.0001. The ELR value for Markis I was significantly higher than for Markis IV (p = 0.04), and three-vessel isolated CAE was significantly higher than onevessel isolated CAE (p = 0.04). Additionally, the ELR value for diffuse ectasia (Markis class I, II and III) was significantly higher compared to focal (Markis class IV) ectasia (p = 0.02). In receiver operating characteristics (ROC) analyses, it was determined that an ELR value > 0.099, measured in isolated CAE patients at application, had a predictive specificity of 60.3% and a sensitivity of 56.5% (area under the curve: 0.604, 95% confidence interval: 0.553-0.655, p < 0.0001). Conclusions: Patients with isolated CAE had higher blood eosinophil counts and ELR. Furthermore, the ELR was significantly correlated with severity of isolated CAE. These findings demonstrate that ELR may have a significant role in the aetiopathogenesis of isolated CAE.

Source

Cardiovascular journal of Africa

Issue

31

URI

https://doi.org/10.5830/CVJA-2019-049
https://hdl.handle.net/20.500.12713/1131

Collections

  • İSÜ Hastaneleri Makale Koleksiyonu [181]
  • PubMed İndeksli Yayınlar Koleksiyonu [1163]
  • Scopus İndeksli Yayınlar Koleksiyonu [1937]
  • WoS İndeksli Yayınlar Koleksiyonu [2061]



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