• A rare case report: bilateral occipital artery arising from the vertebral artery 

  Demirbas, Ahmet Taha; Demirtas, Ismet; Sonmez Topcu, Feyza; Karasu, Sevilay; Ayyildiz, Behcet (Springer Nature, 2021)

  Background Variations of the origin of the occipital artery (OA) can be considered as congenital anomalies that are often asymptomatic and detected incidentally on angiography or during cadaver dissection. While OA ...

• Performing the comparative analysis to understand the functional roles of genes in different pathways of cardiomyopathy disease 

  Atak, Evren; Karaoglu, Dilara; Sertturk, Seda; Koyuncu Irmak, Duygu; Yenenler-Kutlu, Asli (Elsevier, 2021)

  Personalized medicine is one of the popular approaches in biological sciences. Due to the great attention in personalized medicine, there exists a need for health decision algorithms developed through high-level ...

• Cuscuta campestris tedavisi ile mide kanseri hücrelerinde apoptozun indüklenmesi ve reaktif oksijen türlerinin oluşumu yoluyla proliferasyonun engellenmesi 

  Bulut, Huri; Durmus, Ezgi; Hacıosmanoglu, Ebru; Bozali, Kubra; Senturk, Hilal; Kocyigit, Abdurrahim (DergiPark, 2021)

  Amaç: Kanser tahrip edici, ölümcül bir hastalıktır ve dünya çapındaki ölüm nedenleri arasında ikinci sırada yer almaktadır. Mide kanseri gibi kanser türleri için farklı tedavi yöntemleri mevcut olsa da çoğu tedavi yöntemleri ...

• A low direct electrical signal attenuates oxidative stress and inflammation in septic rats 

  Ustunova, Savas; Haciosmanoglu, Ebru; Bulut, Huri; Elibol, Birsen; Kilic, Aysu; Hekimoglu, Rumeysa (PMC, 2021)

  Electrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. ...

• Preparation and characterization of palladium derivate-loaded micelle formulation in vitro as an innovative therapy option against non-small cell lung cancer cells 

  Erkisa, Merve; Ari, Ferda; Buyukkoroglu, Gulay; Senel, Bedriye; Yilmaz, Veysel Turan; Ulukaya, Engin (WILEY, 2021)

  Nanoparticles have been used in cancer treatments to target tumor and reduce side effects. In this study, we aimed to increase the effectiveness of palladium(II) complex [PdCl(terpy)](sac)·2H2O, which previously showed ...

• Diagnosis of endometriosis using endometrioma volume and vibrational spectroscopy with multivariate methods as a noninvasive method 

  Guleken, Zozan; Bulut, Huri; Depciuch, Joanna; Tarhan, Nevzat (Elsevier Science, 2022)

  Endometriomas are typically an advanced form of endometriosis that leads to the formation of scar tissue, adhesions, and an inflammatory reaction. There is no certain serum marker for the diagnosis of endometriosis. This ...

• Water-soluble silver(I) complexes with N-donor benzimidazole ligands containing an imidazolium core: stability and preliminary biological studies 

  Karatas, Mert Olgun; Ozdemir, Namik; Sariman, Melda; Gunal, Selami; Ulukaya, Engin; Ozdemir, Ismail (Royal Society of Chemistry, 2021)

  Herein, we report the synthesis, characterisation and preliminary biological evaluation of two novel silver(I) complexes of type [AgL2](NO3)3 (3 and 4) with ionic N-donor benzimidazoles. The complexes have been synthesized ...

• Palladium (II) complex and thalidomide intercept angiogenic signaling via targeting FAK/Src and Erk/Akt/PLC gamma dependent autophagy pathways in human umbilical vein endothelial cells 

  Aydinlik, Seyma; Uvez, Ayca; Kiyan, Hulya Tuba; Gurel-Gurevin, Ebru; Yilmaz, Veysel Turan; Ulukaya, Engin (Elsevier, 2021)

  The current study assessed the effects of the thalidomide and palladium (II) saccharinate complex of terpyridine on the suppression of angiogenesis-mediated cell proliferation. The viability was assessed after treatment ...

• Serum neprilysin levels are elevated in preeclampsia 

  Tüten, Nevin; Malik, Eduard; Gök, Koray; Hamzaoğlu, Kübra; Makul, Melike; Öner, Yahya Özgün; Bulut, Huri; Tüten, Abdullah; Güralp, Onur Şahin (Elsevier Ltd, 2021)

  Objective: To evaluate the possible associations between serum Neprilysin (NEP) levels and preeclampsia and mild and severe preeclampsia subgroups. Materials and methods: Fifty-five consecutive women with mild preeclampsia ...

• Comparison of four phenotypic assays and check-direct CPE for detection of carbapenemases-producing enterobacterales 

  Abulaila, Ayham; Erdem, Fatma; Öncül, Oral; Aktaş, Zerrin (Verlag Klinisches Labor GmbH, 2021)

  Background: Early and accurate detection of carbapenemase-producing Enterobacterales (CPE) is fundamental to prevent their spread in hospital environment. Our objective was to compare between four commonly used phenotypic ...

• Assessment of the effect of endocrine abnormalities on biomacromolecules and lipids by FT-IR and biochemical assays as biomarker of metabolites in early Polycystic ovary syndrome women 

  Guleken, Zozan; Bulut, Huri; Bulut, Berk; Depciuch, Joanna (Elsevier, 2021)

  Polycystic ovary syndrome (PCOS) is a common endocrinopathy associated with metabolic disturbances.Both in the development and improvement of the disease, the structure of phospholipids and proteinsin the blood serum plays ...

• Annexin A1 as a potential prognostic biomarker for COVID-19 disease: case-control study 

  Canacik, Omer; Sabirli, Ramazan; Altintas, Emel; Karsli, Emre; Karis, Denizhan; Kaymaz, Buse (Wiley, 2021)

  Background: Annexin A1 (AnxA1) is an important endogenous glucocoticoid protein that contributes to the suppression of inflammation by limiting the production of neutrophil and proinflammatory cytokines.This study aims to ...

• Mesenchymal stem cells for the treatment of covid-19: why and when they should be used? 

  Darici, Hakan; Sun, Eda; Irmak, Duygu Koyuncu; Karaöz, Erdal (Nova Science Publishers, 2020)

  COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which caused deaths of more than 300.000 people around the world within the first few months of 2020. SARS-CoV-2 uses ACE2 ...

• Functional recovery after wharton’s jelly–derived mesenchymal stem cell administration in a patient with traumatic spinal cord injury: a pilot study 

  Kabatas, Serdar; Civelek, Erdinc; Savrunlu, Eyup Can; Kaplan, Necati; Cetin, Ercan; Diren, Furkan; Boyali, Osman; Guven, Goksel; Karaoz, Erdal (Gelenos, 2021)

  The use of stem cells in the treatment of traumatic spinal cord injury (SCI) in recent years has provided promising results. Different sources of cells for transplantation have been used, including mesenchymal stem cells ...

• The promising effects of BMP2 transfected mesenchymal stem cells on human osteosarcoma 

  Sari, Ahmet Sinan; Demircay, Emre; Ozturk, Ahmet; Terzi, Aysen; Karaoz, Erdal (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2021)

  Selective targeting of transfected mesenchymal stem cells (MSCs) carrying specific antioncogenes to the tumor was suggested as a treatment option. Bone morphogenetic protein-2 (BMP2) was shown to inhibit the proliferation ...

• Mesenchymal stem cells derived from epicardial adipose tissue reverse cardiac remodeling in a rabbit model of myocardial infarction 

  Özkaynak, Berk; Şahin, İrfan; Özenc, E.; Subaşı, Cansu; Oran, Duygu Sultan; Totoz, Tolga; Tetikkurt, Ümit Seza; Mert, Bülent; Polat, Adil; Okuyan, Ertuǧrul; Karaöz, Erdal (Verduci Editore s.r.l, 2021)

  OBJECTIVE: Myocardial infarction (MI) is one of the most important causes of death. MI-related tissue loss and cardiac remodeling may result in heart failure. Intramyocardial injection of mesenchymal stem cells derived ...

• The systematic effect of mesenchymal stem cell therapy in critical COVID-19 patients: a prospective double controlled trial 

  Adas, G.; Cukurova, Z.; Kart Yasar, K.; Yilmaz, R.; Isiksacan, N.; Kasapoglu, P.; Yesilbag, Z.; Koyuncu, I. D.; Karaoz, E. (Sage Journals, 2021)

  The aim of this clinical trial was to control the cytokine storm by administering mesenchymal stem cells (MSCs) to critically-ill COVID-19 patients, to evaluate the healing effect, and to systematically investigate how the ...

• Tumor chemosensitivity assays are helpful for personalized cytotoxic treatments in cancer patients 

  Ulukaya, Engin; Karakas, Didem; Dimas, Konstantinos (MDPI, 2021)

  Tumor chemosensitivity assays (TCAs), also known as drug response assays or individualized tumor response tests, have been gaining attention over the past few decades. Although there have been strong positive correlations ...

• Angiotensin IV improves spatial memory in streptozotocin‑induced diabetic rats by reducing oxidative stress and altering BDNF levels 

  Kilic, Aysu; Ustunova, Savas; Elibol, Birsen; Bulut, Huri; Meral, Ismail; Sahin, Gulderen (NCI CPTAC, 2021)

  In this study, we investigated the protective effects of angiotensin IV (Ang IV) on cognitive function in streptozotocin (STZ)‑induced diabetic rats. Male Wistar albino rats, were randomly divided into four groups; control ...

• Expression analysis in the transcription level of PTGS2, CALR, MAGE-A3 genes in non-small cell lung cancer 

  Kose, Busra; Bozkurt, Sureyya (DergiPark, 2020)

  Background: In lung cancer, expression changes in genes that indirectly trigger carcinogenesis are a remarkable issue. In addition to mutations, detection of expression of genes that affect cell division, apoptosis, ...

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