• Mesenchymal stem cells for the treatment of covid-19: why and when they should be used? 

  Darici, Hakan; Sun, Eda; Irmak, Duygu Koyuncu; Karaöz, Erdal (Nova Science Publishers, 2020)

  COVID-19 is a pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which caused deaths of more than 300.000 people around the world within the first few months of 2020. SARS-CoV-2 uses ACE2 ...

• Functional recovery after wharton’s jelly–derived mesenchymal stem cell administration in a patient with traumatic spinal cord injury: a pilot study 

  Kabatas, Serdar; Civelek, Erdinc; Savrunlu, Eyup Can; Kaplan, Necati; Cetin, Ercan; Diren, Furkan; Boyali, Osman; Guven, Goksel; Karaoz, Erdal (Gelenos, 2021)

  The use of stem cells in the treatment of traumatic spinal cord injury (SCI) in recent years has provided promising results. Different sources of cells for transplantation have been used, including mesenchymal stem cells ...

• The promising effects of BMP2 transfected mesenchymal stem cells on human osteosarcoma 

  Sari, Ahmet Sinan; Demircay, Emre; Ozturk, Ahmet; Terzi, Aysen; Karaoz, Erdal (TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY, 2021)

  Selective targeting of transfected mesenchymal stem cells (MSCs) carrying specific antioncogenes to the tumor was suggested as a treatment option. Bone morphogenetic protein-2 (BMP2) was shown to inhibit the proliferation ...

• Mesenchymal stem cells derived from epicardial adipose tissue reverse cardiac remodeling in a rabbit model of myocardial infarction 

  Özkaynak, Berk; Şahin, İrfan; Özenc, E.; Subaşı, Cansu; Oran, Duygu Sultan; Totoz, Tolga; Tetikkurt, Ümit Seza; Mert, Bülent; Polat, Adil; Okuyan, Ertuǧrul; Karaöz, Erdal (Verduci Editore s.r.l, 2021)

  OBJECTIVE: Myocardial infarction (MI) is one of the most important causes of death. MI-related tissue loss and cardiac remodeling may result in heart failure. Intramyocardial injection of mesenchymal stem cells derived ...

• The systematic effect of mesenchymal stem cell therapy in critical COVID-19 patients: a prospective double controlled trial 

  Adas, G.; Cukurova, Z.; Kart Yasar, K.; Yilmaz, R.; Isiksacan, N.; Kasapoglu, P.; Yesilbag, Z.; Koyuncu, I. D.; Karaoz, E. (Sage Journals, 2021)

  The aim of this clinical trial was to control the cytokine storm by administering mesenchymal stem cells (MSCs) to critically-ill COVID-19 patients, to evaluate the healing effect, and to systematically investigate how the ...

• Tumor chemosensitivity assays are helpful for personalized cytotoxic treatments in cancer patients 

  Ulukaya, Engin; Karakas, Didem; Dimas, Konstantinos (MDPI, 2021)

  Tumor chemosensitivity assays (TCAs), also known as drug response assays or individualized tumor response tests, have been gaining attention over the past few decades. Although there have been strong positive correlations ...

• Angiotensin IV improves spatial memory in streptozotocin‑induced diabetic rats by reducing oxidative stress and altering BDNF levels 

  Kilic, Aysu; Ustunova, Savas; Elibol, Birsen; Bulut, Huri; Meral, Ismail; Sahin, Gulderen (NCI CPTAC, 2021)

  In this study, we investigated the protective effects of angiotensin IV (Ang IV) on cognitive function in streptozotocin (STZ)‑induced diabetic rats. Male Wistar albino rats, were randomly divided into four groups; control ...

• Expression analysis in the transcription level of PTGS2, CALR, MAGE-A3 genes in non-small cell lung cancer 

  Kose, Busra; Bozkurt, Sureyya (DergiPark, 2020)

  Background: In lung cancer, expression changes in genes that indirectly trigger carcinogenesis are a remarkable issue. In addition to mutations, detection of expression of genes that affect cell division, apoptosis, ...

• Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses 

  Kilic, Derya; Yetimalar, Mehmet Hakan; Koseoglu, Mehmet; Saglam, Gulcan (DergiPark, 2020)

  Abstract Purpose: Human epididymis factor 4 (HE4) is a novel biomarker for ovarian cancer. The aim of this study is to assess the usefulness and efficacy of HE4, in comparison with CA-125 in the differential diagnosis ...

• Analysis of serum nickel, silicium, arsenic and boron in smoking ındividuals 

  Ates Alkan, Fatma; Karis, Denizhan; Cakmak Uzan, Gulfidan; Ercan, Alev Meltem (DergiPark, 2021)

  Smoking induces inflammation and oxidative stress via radical production from chemicals resulting in cardiocerebrovascular and respiratory diseases, cancers, stroke and sudden death. Elements found in tobacco plant and ...

• Prognostic biomarkers in lung cancer patients in terms of long-term survival 

  Coskun, Belkis Nihan; Dizdar, Oguzhan Sitki; Korkmaz, Seniz; Ulukaya, Engin; Evrensel, Turkkan (DergiPark, 2021)

  Introduction: We aimed to investigate the predictive effect of serum M30 and M65 antigens on long-term prognosis in patients with advanced stage lung cancer before and after the first dose of chemotherapy. Methods: Fourty ...

• Aurasız migren hastalarının farklı frekanslardaki görsel uyarılmış potansiyeller ile değerlendirilmesi 

  Atac, Ceyla; Tuna Erdogan, Ezgi (2020)

  Giriş ve Amaç: Çalışmamızın amacı, International Society for Clinical Electrophysiology of Vision (ISCEV) standartlarına göre, aurasız migren hastalarında, iki farklı kontrol boyutu (15 've 62') ile kaydedilen tersine ...

• The novel translocation of t (1;21) in multiple myeloma with poor prognosis 

  Okay, Mufide; Bozkurt, Sureyya; Ozgeyik, Mehmet; Haznedaroglu, Ibrahim Celalettin (DergiPark, 2019)

  Objective: Multiple myeloma (MM) is characterized as the neoplastic proliferation of plasma cells producing a monoclonal paraprotein. The aim of this paper is to report complex karyotype that leads to a fatal clinical ...

• Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: phase I study 

  Kabatas, Serdar; Civelek, Erdinç; Savrunlu, Eyüp Can; Kaplan, Necati; Boyalı, Osman; Diren, Furkan; Can, Halil; Genç, Ali; Akkoç, Tunç; Karaoz, Erdal (Baishideng Publishing Group Co, 2021)

  Background Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of death and long-term neurological impairment in the pediatric population. Despite a limited number of treatments to cure HIE, stem cell therapies ...

• Family-centered lactation counseling and breastfeeding in preterm infants upon neonatal intensive care discharge 

  Ongun, Hakan; Demir, Meltem (WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2021)

  Background: There is great variability in breastfeeding implications upon neonatal intensive care unit discharge for preterm infants. Aims and Objectives: To examine the breastfeeding rates and the impact of lactation-counseling ...

• Prevalence methıcıllın-resıstant staphylococcus aureus (Mrsa) nasal carrıage among healthy students of medıcal schools in Istanbul (Turkey) 

  Torun, Muzeyyen; Berk, Selimcan; Arslan, Utku; Yokuş, Burhan; Erden, Agin; Cayıt, Batıgül; Onlen, Behiye Begüm; Mestanoğlu, Mert; Saglam, Filiz Yarımcan; Aktepe, Orhan Cem (Bulgarian Society for Microbiology (Union of Scientists in Bulgaria), 2018)

  Nasal carriage of MRSA plays a key role in the epidemiology and pathogenesis of staphylococcal infections. The aim of this study is to examine nasal MRSA carriage among healthy pre-clinical and clinical medical students ...

• Safety and efficacy of the stem cell transplantation in friedreich's ataxia: a report of three cases 

  Azeri, Riza; Irmak, Duygu Koyuncu; Sun, Eda; Karaoz, Erdal (IJPHY PUBLISHERS, 2021)

  Background: Friedreich's ataxia is a progressive degenerative disorder caused by deficiency of the frataxin protein. Expanded GAA repeats in intron 1 of the FXN gene lead to its heterochromatinization and transcriptional ...

• Serum survivin is decreased in women with preeclampsia 

  Guralp, Onur; Gok, Koray; Tuten, Nevin; Hamzaoglu, Kubra; Makul, Melike; Bulut, Huri (Taylor & Francis Online, 2021)

  Objective: To evaluate the serum survivin level in preeclampsia.Methods: Eighty-eight pregnancies complicated with preeclampsia and 88 gestational-age (GA)-matched uncomplicated pregnancies were evaluated.Results: Mean ...

• Preparation of glutathione loaded nanoemulsions and testing of hepatoprotective activity on THLE-2 cells 

  Yesiltepe, Ozan; Celik, Emine Guler; Geyik, Caner; Gumus, Zinar Pinar; Demirkol, Dilek Odaci; Coskunol, Hakan; Timur, Suna (SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK, 2021)

  To improve bioavailability and stability of hydrophobic and hydrophilic compounds, nanoemulsions are good alternatives as delivery systems because of their nontoxic and nonirritant nature. Glutathione (GSH) suffers from ...

• Serum catestatin level is increased in women with preeclampsia 

  Tuten, Nevin; Guralp, Onur; Hamzaoglu, Kubra; Oner, Yahya Ozgun; Makul, Melike; Bulut, Huri; Irmak Kubra; Tuten, Abdullah; Malik, Eduard (Taylor And Francis, 2021)

  Catestatin can inhibit catecholamine release from chromaffin cells and adrenergic neurons. Catestatin can also have a strong vasodilator effect. This may be useful in understanding the pathophysiology of preeclampsia and ...

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