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dc.contributor.authorKori, Medi
dc.contributor.authorAydin, Busra
dc.contributor.authorGulfidan, Gizem
dc.contributor.authorBeklen, Hande
dc.contributor.authorKelesoglu, Nurdan
dc.contributor.authorCaliskan Iscan, Aysegul
dc.contributor.authorTuranli, Beste
dc.contributor.authorErzik, Can
dc.contributor.authorKarademir, Betul
dc.contributor.authorArga, Kazim Yalcin
dc.date.accessioned2021-01-11T07:34:06Z
dc.date.available2021-01-11T07:34:06Z
dc.date.issued2021en_US
dc.identifier.citationKori, M., Aydin, B., Gulfidan, G., Beklen, H., Kelesoglu, N., Caliskan Iscan, A., Turanli, B., Erzik, C., Karademir, B., & Arga, K. Y. (2021). The Repertoire of Glycan Alterations and Glycoproteins in Human Cancers. Omics : a journal of integrative biology, 10.1089/omi.2020.0210. Advance online publication. https://doi.org/10.1089/omi.2020.0210en_US
dc.identifier.issn1536-2310
dc.identifier.issn1557-8100
dc.identifier.urihttps://doi.org/10.1089/omi.2020.0210
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1308
dc.description.abstractCancer as the leading cause of death worldwide has many issues that still need to be addressed. Since the alterations on the glycan compositions or/and structures (i.e., glycosylation, sialylation, and fucosylation) are common features of tumorigenesis, glycomics becomes an emerging field examining the structure and function of glycans. In the past, cancer studies heavily relied on genomics and transcriptomics with relatively little exploration of the glycan alterations and glycoprotein biomarkers among individuals and populations. Since glycosylation of proteins increases their structural complexity by several orders of magnitude, glycome studies resulted in highly dynamic biomarkers that can be evaluated for cancer diagnosis, prognosis, and therapy. Glycome not only integrates our genetic background with past and present environmental factors but also offers a promise of more efficient patient stratification compared with genetic variations. Therefore, studying glycans holds great potential for better diagnostic markers as well as developing more efficient treatment strategies in human cancers. While recent developments in glycomics and associated technologies now offer new possibilities to achieve a high-throughput profiling of glycan diversity, we aim to give an overview of the current status of glycan research and the potential applications of the glycans in the scope of the personalized medicine strategies for cancer.en_US
dc.language.isoengen_US
dc.relation.isversionof10.1089/omi.2020.0210en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanceren_US
dc.subjectFucosylation and Personalized Medicineen_US
dc.subjectGlycanen_US
dc.subjectGlycan Alterationen_US
dc.subjectGlycoproteinen_US
dc.subjectGlycosylationen_US
dc.subjectSialylationen_US
dc.subjectTumoren_US
dc.titleThe repertoire of glycan alterations and glycoproteins in human cancersen_US
dc.typearticleen_US
dc.contributor.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Temel Bilimleri Bölümüen_US
dc.contributor.institutionauthorCaliskan Iscan, Aysegul
dc.relation.journalOMICSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000628899900003en_US
dc.description.pubmedpublicationid33404348en_US
dc.description.wosqualityQ2en_US


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