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The role of LncRNAs in translation

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Date

2021

Author

Karakas, Didem
Ozpolat, Bulent

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Citation

Karakas, D.; Ozpolat, B. The Role of lncRNAs in Translation. Non-coding RNA 2021, 7, 16. https://doi.org/10.3390/ncrna7010016

Abstract

Abstract: Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins and regulate gene expression at the transcriptional, post-transcriptional, translational, and posttranslational levels. Depending on cellular location, lncRNAs are involved in a wide range of cellular functions, including chromatin modification, transcriptional activation, transcriptional interference, scaffolding and regulation of translational machinery. This review highlights recent studies on lncRNAs in the regulation of protein translation by modulating the translational factors (i.e, eIF4E, eIF4G, eIF4A, 4E-BP1, eEF5A) and signaling pathways involved in this process as wells as their potential roles as tumor suppressors or tumor promoters.

Source

Non-coding RNA

Volume

7

Issue

16

URI

https://doi.org/10.3390/ncrna7010016
https://hdl.handle.net/20.500.12713/1516

Collections

  • Moleküler Biyoloji ve Genetik Bölümü Makale Koleksiyonu [54]
  • PubMed İndeksli Yayınlar Koleksiyonu [1153]
  • Scopus İndeksli Yayınlar Koleksiyonu [1892]
  • WoS İndeksli Yayınlar Koleksiyonu [1969]



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