The role of LncRNAs in translation
Citation
Karakas, D.; Ozpolat, B. The Role of lncRNAs in Translation. Non-coding RNA 2021, 7, 16. https://doi.org/10.3390/ncrna7010016Abstract
Abstract: Long non-coding RNAs (lncRNAs), a group of non-protein coding RNAs with lengths of
more than 200 nucleotides, exert their effects by binding to DNA, mRNA, microRNA, and proteins
and regulate gene expression at the transcriptional, post-transcriptional, translational, and posttranslational levels. Depending on cellular location, lncRNAs are involved in a wide range of cellular functions, including chromatin modification, transcriptional activation, transcriptional interference, scaffolding and regulation of translational machinery. This review highlights recent studies
on lncRNAs in the regulation of protein translation by modulating the translational factors (i.e,
eIF4E, eIF4G, eIF4A, 4E-BP1, eEF5A) and signaling pathways involved in this process as wells as
their potential roles as tumor suppressors or tumor promoters.