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Prognostic value of HPV DNA in urothelial carcinoma of the bladder: a preliminary report of 2-year follow-up results

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Date

2021

Author

Sarier, Mehmet
Suremen Usta, Sibel
Turgut, Hasan
Ozturk, Sefa Alperen
Soylu, Ahmet
Emek, Mestan
Kukul, Erdal
Bozcuk, Hakan
Sepin, Nevgun

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Citation

Sarier, M., Usta, S. S., Turgut, H., Öztürk, S. A., Soylu, A., Emek, M., Kukul, E., Bozcuk, H., & Sepin, N. (2021). Prognostic value of HPV DNA in Urothelial Carcinoma of the Bladder: A Preliminary Report of 2-Year Follow-up Results. Urology journal, 10.22037/uj.v18i.6429. Advance online publication. https://doi.org/10.22037/uj.v18i.6429

Abstract

Purpose: The association between the human papillomavirus (HPV) and anogenital carcinomas is well established. However, despite its anatomic adjacency, the relationship between HPV and urothelial carcinoma of the bladder (UCB) is less clear. Recent meta-analysis and case-control studies demonstrated a significant relationship between the presence of HPV DNA and UCB. The aim of this clinical study was to compare the 2-year follow-up results of HPV-positive and HPV-negative UCB patients to evaluate the prognostic value of HPV DNA positivity in UCB. Methods: The study included patients with stage pTa and pT1 UCB who underwent polymerase chain reaction (PCR) analysis of HPV DNA between January 1 and November 30, 2018. Based on their PCR results, 19 HPV-positive and 38 HPV-negative UCB patients who had regular follow-up in our clinic were evaluated in terms of tumor recurrence and disease progression over a 2-year follow-up period. Results: There was no significant difference between the groups in terms of age, follow-up time, smoking, or tumor grade (P= .576, P= .368, P= .080, and P= .454). Tumor recurrence was observed at least once in 47.3% (n=9) of the 19 HPV-positive patients and 36.8% (n=14) of the 38 HPV-negative patients (P= .445). There was no difference in disease progression between the groups during follow-up. Conclusion: In our sample of UCB patients, the presence of HPV DNA was associated with a trend toward higher recurrence rate during the 2-year follow-up, though the difference was not statistically significant. No difference in disease progression was observed based on HPV DNA positivity.

Source

Urology Journal

URI

https://doi.org/10.22037/uj.v18i.6429
https://hdl.handle.net/20.500.12713/1714

Collections

  • Diyaliz Programı Makale Koleksiyonu [17]
  • PubMed İndeksli Yayınlar Koleksiyonu [1153]
  • Scopus İndeksli Yayınlar Koleksiyonu [1892]



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