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Serum catestatin level is increased in women with preeclampsia

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Date

2021

Author

Tuten, Nevin
Guralp, Onur
Hamzaoglu, Kubra
Oner, Yahya Ozgun
Makul, Melike
Bulut, Huri
Irmak Kubra
Tuten, Abdullah
Malik, Eduard

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Citation

Tüten, N., Güralp, O., Gök, K., Hamzaoglu, K., Oner, Y. O., Makul, M., Bulut, H., Irmak, K., Tüten, A., & Malik, E. (2021). Serum catestatin level is increased in women with preeclampsia. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 1–6. Advance online publication. https://doi.org/10.1080/01443615.2021.1873922

Abstract

Catestatin can inhibit catecholamine release from chromaffin cells and adrenergic neurons. Catestatin can also have a strong vasodilator effect. This may be useful in understanding the pathophysiology of preeclampsia and its treatment. In this study, we investigated the serum catestatin levels in pregnant women with and without preeclampsia. Fifty consecutive women with mild preeclampsia, 50 consecutive women with severe preeclampsia, and 100 consecutive pregnant women with a gestational age-matched (±1 week) uncomplicated pregnancy were evaluated in a cross-sectional study. Mean serum catestatin was significantly increased in the preeclampsia group compared to the control group (290.7 ± 95.5 pg/mL vs. 182.8 ± 72.0 pg/mL). Mean serum catestatin was comparable in mild and severe preeclampsia groups (282.7 ± 97.9 pg/mL vs. 298.7 ± 93.4 pg/mL, p = .431). Serum catestatin levels had positive correlations with systolic and diastolic blood pressure, urea, uric acid, and creatinine. In conclusion, serum catestatin levels are increased in preeclamptic pregnancies compared to gestational age-matched controls.IMPACT STATEMENTWhat is already known on this subject? The role of autonomic nervous system dysregulation in the pathophysiology of preeclampsia is known. The most obvious part of this dysregulation is the sympathetic nervous system activation. The adrenal medulla is one of the locations of the sympathetic nervous system in the body.What do the results of this study add? Serum catestatin levels were found to be correlated with clinical and laboratory data of preeclampsia. This highlights the importance of chromaffin cell secretions in the adrenal medulla in preeclampsia.What are the implications of these findings for clinical practice and/or further research? This study will help understand the role of the adrenal medulla in the autonomic nervous system dysregulation in preeclampsia. Also, control of serum catestatin levels may support the treatment of hypertension in preeclampsia.

Source

Journal of Obstetrics and Gynaecology

URI

https://doi.org/10.1080/01443615.2021.1873922
https://hdl.handle.net/20.500.12713/1725

Collections

  • Cerrahi Tıp Bilimleri Bölümü Makale Koleksiyonu [306]
  • PubMed İndeksli Yayınlar Koleksiyonu [1163]
  • Scopus İndeksli Yayınlar Koleksiyonu [1937]
  • Temel Tıp Bilimleri Bölümü Makale Koleksiyonu [236]
  • WoS İndeksli Yayınlar Koleksiyonu [2061]



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