Serum survivin is decreased in women with preeclampsia
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CitationGüralp, O., Gök, K., Tüten, N., Hamzaoglu, K., Makul, M., Oner, Y. O., Bulut, H., Schild-Suhren, M., Malik, E., & Tüten, A. (2021). Serum survivin is decreased in women with preeclampsia. Hypertension in pregnancy, 1–8. Advance online publication. https://doi.org/10.1080/10641955.2021.1917601
Objective: To evaluate the serum survivin level in preeclampsia.Methods: Eighty-eight pregnancies complicated with preeclampsia and 88 gestational-age (GA)-matched uncomplicated pregnancies were evaluated.Results: Mean serum survivin was detected to be significantly decreased in the early- (EOPE) and late-onset (LOPE) preeclampsia subgroups than the GA-matched control-groups; and were comparable in EOPE- and LOPE-groups after correction for GA. Serum survivin had weak negative correlations with systolic and diastolic arterial blood pressure.Conclusion: The serum survivin level was decreased in preeclamptic patients than the GA-matched controls. More comprehensive studies are needed to clarify the timing and extent of placental apoptosis in preeclampsia.