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dc.contributor.authorGuven, Deniz C.
dc.contributor.authorAktepe, Oktay H.
dc.contributor.authorTaban, Hakan
dc.contributor.authorAktas, Burak Y.
dc.contributor.authorGuner, Gurkan
dc.contributor.authorYildirim, Hasan C.
dc.contributor.authorKilickap, Saadettin
dc.date.accessioned2021-08-19T06:38:39Z
dc.date.available2021-08-19T06:38:39Z
dc.date.issued2021en_US
dc.identifier.citationGuven, D. C., Aktepe, O. H., Taban, H., Aktas, B. Y., Guner, G., Yildirim, H. C., Sahin, T. K., Aksun, M. S., Dizdar, O., Aksoy, S., Erman, M., Yalcin, S., & Kilickap, S. (2021). Lower prognostic nutritional index is associated with poorer survival in patients receiving ımmune-checkpoint ınhibitors. Biomarkers in medicine, 10.2217/bmm-2020-0674. Advance online publication. https://doi.org/10.2217/bmm-2020-0674en_US
dc.identifier.urihttps://doi.org/10.2217/bmm-2020-0674
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2003
dc.description.abstractAim: Blood-based biomarkers like prognostic nutritional index (PNI) are readily available biomarkers for immunotherapy efficacy, although the data are limited. So, we aimed to evaluate the association between PNI and overall survival (OS) in immunotherapy-treated patients. Materials & methods: For this retrospective cohort study, data of 150 immunotherapy-treated advanced cancer patients were evaluated. The association between clinical factors and OS was evaluated with multivariate Cox-regression analyses. Results: After a median follow-up of 8.5 months, 94 patients died. The median OS was 11.07 months. The low PNI (hazard ratio [HR]: 2.065; p = 0.001), high lactate dehydrogenase (HR: 2.515; p = 0.001) and poor Eastern Cooperative Oncology Group (ECOG) status (HR: 2.164; p = 0.009) was associated with poorer OS in multivariate analyses. Conclusion: In our experience, survival with immunotherapy was impaired in patients with lower PNI and higher lactate dehydrogenase levels and poorer ECOG status.en_US
dc.language.isoengen_US
dc.publisherFuture Medicineen_US
dc.relation.isversionof10.2217/bmm-2020-0674en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectECOGen_US
dc.subjectLDHen_US
dc.subjectBiomarkersen_US
dc.subjectImmunotherapyen_US
dc.subjectPrognostic Nutritional Indexen_US
dc.titleLower prognostic nutritional index is associated with poorer survival in patients receiving ımmune-checkpoint ınhibitorsen_US
dc.typearticleen_US
dc.contributor.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.contributor.authorID0000-0003-1637-7390en_US
dc.contributor.institutionauthorKilickap, Saadettin
dc.relation.journalBiomarkers in Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000685162800001
dc.description.pubmedpublicationid34397271en_US
dc.description.wosqualityQ3


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