A low direct electrical signal attenuates oxidative stress and inflammation in septic rats

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2021Author
Ustunova, SavasHaciosmanoglu, Ebru
Bulut, Huri
Elibol, Birsen
Kilic, Aysu
Hekimoglu, Rumeysa
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Ustunova, S., Haciosmanoglu, E., Bulut, H., Elibol, B., Kilic, A., Hekimoglu, R., Tunc, S., Atmaca, R., Kaygusuz, I., Tunc, S., Tunc, G. B., & Meral, I. (2021). A low direct electrical signal attenuates oxidative stress and inflammation in septic rats. PloS one, 16(9), e0257177. https://doi.org/10.1371/journal.pone.0257177Abstract
Electrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar albino rats were divided into 4
groups: healthy control (C), electrified healthy (E), sepsis (S), and electrified sepsis (SE)
groups. Staphylococcus aureus (1 x 109 colonies) in 1 ml of medium was intraperitoneally
injected into rats to produce a sepsis model. The rats in the E and SE groups were exposed
to a low direct electrical signal (300 Hz and 2.5 volts) for 40 min and 1 and 6 h after bacterial
infection. Immediately after the second electrical signal application, blood and tissue samples of the heart, lung, and liver were collected. An antibacterial effect of a low direct electrical signal was observed in the blood of rats. The effects of electrical signals on ameliorating
changes in the histological structure of tissues, blood pH, gases, viscosity and cell count,
activities of some important enzymes, oxidative stress parameters, inflammation and tissue
apoptosis were observed in the SE group compared to the S group. Low direct electrical signal application exerts antibacterial, antioxidant, anti-inflammatory and antiapoptotic effects
on septic rats due to the induction of electrolysis in body fluids without producing any tissue
damage.