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Targeting cancer stem cells by dietary agents: an important therapeutic strategy against human malignancies

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Date

2021

Author

Paskeh, Mahshid Deldar Abad
Asadi, Shafagh
Zabolian, Amirhossein
Saleki, Hossein
Khoshbakht, Mohammad Amin
Zarrabi, Ali

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Citation

Deldar Abad Paskeh, M., Asadi, S., Zabolian, A., Saleki, H., Khoshbakht, M. A., Sabet, S., ... & Sethi, G. (2021). Targeting Cancer Stem Cells by Dietary Agents: An Important Therapeutic Strategy against Human Malignancies. International Journal of Molecular Sciences, 22(21), 11669.

Abstract

As a multifactorial disease, treatment of cancer depends on understanding unique mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for tumor stemness and by enhancing colony formation, proliferation as well as metastasis, and these cells can also mediate resistance to therapy. Furthermore, the presence of CSCs leads to cancer recurrence and therefore their complete eradication can have immense therapeutic benefits. The present review focuses on targeting CSCs by natural products in cancer therapy. The growth and colony formation capacities of CSCs have been reported can be attenuated by the dietary agents. These compounds can induce apoptosis in CSCs and reduce tumor migration and invasion via EMT inhibition. A variety of molecular pathways including STAT3, Wnt/β-catenin, Sonic Hedgehog, Gli1 and NF-κB undergo down-regulation by dietary agents in suppressing CSC features. Upon exposure to natural agents, a significant decrease occurs in levels of CSC markers including CD44, CD133, ALDH1, Oct4 and Nanog to impair cancer stemness. Furthermore, CSC suppression by dietary agents can enhance sensitivity of tumors to chemotherapy and radiotherapy. In addition to in vitro studies, as well as experiments on the different preclinical models have shown capacity of natural products in suppressing cancer stemness. Furthermore, use of nanostructures for improving therapeutic impact of dietary agents is recommended to rapidly translate preclinical findings for clinical use. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Source

International Journal of Molecular Sciences

Volume

22

Issue

21

URI

https://doi.org/10.3390/ijms222111669
https://hdl.handle.net/20.500.12713/2210

Collections

  • Biyomedikal Mühendisliği Bölümü Makale Koleksiyonu [64]
  • Cerrahi Tıp Bilimleri Bölümü Makale Koleksiyonu [306]
  • PubMed İndeksli Yayınlar Koleksiyonu [1162]
  • Scopus İndeksli Yayınlar Koleksiyonu [1924]
  • WoS İndeksli Yayınlar Koleksiyonu [2043]



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