Epstein‑Barr virus‑related lymphoproliferative disorders in T‑cell repleted haploidentical transplantation with post‑transplant cyclophosphamide
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CitationUygun, V., Özsan, N., Daloğlu, H., Öztürkmen, S., Yalçın, K., Karasu, G., & Yeşilipek, A. (2021). Epstein-Barr virus-related lymphoproliferative disorders in T-cell repleted haploidentical transplantation with post-transplant cyclophosphamide. International journal of hematology, 10.1007/s12185-021-03267-8. Advance online publication.
EBV-associated lymphoproliferative disorders (LPDs) are common in hematopoietic stem cell transplantation (HSCT) with T-cell-depleted grafts, but are extremely rare in HSCT patients with T-cell-replete grafts with post-transplant cyclophosphamide (PTCy). Here we present the cases of two pediatric patients who developed EBV-related LPD after T-cell-replete haplo-HSCT with PTCy. One of these is the first reported case of EBV-positive mucocutaneous ulcer (EBVMCU) developing after PTCy. EBV-related diseases are rare in T-cell-replete haplo-HSCT patients with PTCy. However, in patients with risk factors, it is reasonable to screen for EBV viremia for LPD.