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Evaluation of modified pectin/alginate buccal patches with enhanced mucoadhesive properties for drug release systems: in-vitro and ex-vivo study

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Date

2022

Author

Özbaş, Zehra
Özkahraman, Bengi
Püren Akgüner, Zeynep
Bal Öztürk, Ayça

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Citation

Özbaş, Z., Özkahraman, B., Akgüner, Z. P., & Bal-Öztürk, A. (2021). Evaluation of modified pectin/alginate buccal patches with enhanced mucoadhesive properties for drug release systems: In-vitro and ex-vivo study. Journal of Drug Delivery Science and Technology, 102991.

Abstract

A recent approach for buccal mucoadhesive system is the production of thiolated polymers via thiomer. In this study, pectin was grafted with acrylic acid before the thiolation by L-cystein and it was characterized by FTIR, 1H NMR, and TGA. Following that, modified/unmodified pectin and alginate patches were successfully fabricated by a casting method, and they were characterized by FTIR and TGA. The modified pectin/alginate patches had a higher swelling ratio than that of unmodified pectin/alginate patches. Moreover, ex-vivo mucoadhesion studies of modified pectin/alginate buccal patch was 0.11 ± 0.033 N which meant that mucoadhesion on buccal mucosa was improved as compared to unmodified pectin/alginate buccal patch. The triamcinolone acetonide release capacity of the modified pectin/alginate and unmodified pectin/alginate patches in pH 6.8 was found to be 32.6 and 28.5 mg/g, respectively. The drug release kinetic data best fitted with Korsmeyer-Peppas model for both buccal patches. To cell culture studies, drug loaded, and unloaded buccal patches had no cytotoxicity against L929 cell line. According to our results modified pectin/alginate buccal patch can be used as a promising alternative for buccal mucoadhesive drug release systems.

Source

Journal of Drug Delivery Science and Technology

Volume

67

URI

https://doi.org/10.1016/j.jddst.2021.102991
https://hdl.handle.net/20.500.12713/2341

Collections

  • Scopus İndeksli Yayınlar Koleksiyonu [1924]
  • WoS İndeksli Yayınlar Koleksiyonu [2043]



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