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dc.contributor.authorOzdilli, Kursat
dc.contributor.authorOguz, Fatma Savran
dc.contributor.authorAnak, Sema
dc.contributor.authorOgret, Yeliz
dc.contributor.authorCiftci, Hayriye Senturk
dc.contributor.authorOguz, Rustu
dc.contributor.authorCarin, Mahmut
dc.date.accessioned2022-01-10T07:05:13Z
dc.date.available2022-01-10T07:05:13Z
dc.date.issued2021en_US
dc.identifier.citationÖzdilli, K., Oğuz, F. S., Anak, S., Öğret, Y., Çiftçi, H. Ş., Oğuz, R., & Carin, M. (2021). The Influence of Human Leukocyte Antigens in Graft Versus Host Disease and Survival After Hematopoietic Stem Cell Transplantation in Pediatric Patients with Leukemia. Med J Bakirkoy, 17, 280-285.en_US
dc.identifier.issn1305-9319
dc.identifier.issn1305-9327
dc.identifier.urihttps://doi.org/10.4274/BMJ.galenos.2021.41636
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2382
dc.description.abstractObjective: Hematopoietic stem cell transplantation (HSCT) is an important therapy for hematological diseases. One of the most significant complications of HSCT is graft versus host disease (GVHD), and major histocompatibility complex (MHC) is well known to affect GVHD and graft rejection. This study aimed to examine the effect of human leukocyte antigens (HLA) on the incidence of GVHD development in patients with leukemia. Methods: The association between HLA and GVHD formation was evaluated in 57 patients with HSCT with HLA-identical sibling donors, of whom 37 were boys and 20 were girls with a mean age of 10.11 years. All patients were diagnosed with leukemia; acute myeloid leukemia (n=33), acute lymphoblastic leukemia (n=15), and chronic myeloid leukemia (n=9). Transplantation pairs were worked for HLA-A,-B,-C, and-DRB1 alleles. Class I HLA antigens were investigated using Terasaki microlymphocytotoxicity, whereas class II HLA alleles with polymerase chain reaction -sequence-specific amplification method. Results: The frequency of developing GVHD in patients with HSCT was found to be 17.5% (n=10). HLA-DRB1*04 allelic frequency [p=0.024, odds ratio (OR): 4.87] was found to be higher in patients who developed GVHD. However, the HLA-DRB1*11 allelic frequency (p=0.031, OR: 0.12) was lower in patients who developed GVHD compared to patients who did not develop GVHD. Furthermore, HLA-B38 (p=0.002) and HLA-B41 (p=0.002) antigens were found only in patients who developed GVHD. The frequencies of the HLA-A26 allele (p=0.12) and the HLADRB1*11 allele (p=0.037, OR: 4.0) were higher in patients with relapse after HSCT; however, the frequencies of the HLA-A2 allele (p=0.033, OR: 0.19) was lower in patients who relapsed after HSCT. Conclusion: This study assessed the relationship of HLA class with GVHD, relapse, and survival in children after HSCT in pediatric patients with leukemia.en_US
dc.language.isoengen_US
dc.publisherGALENOS YAYINCILIKen_US
dc.relation.isversionof10.4274/BMJ.galenos.2021.41636en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGVHDen_US
dc.subjectLeukemiaen_US
dc.subjectHSCTen_US
dc.subjectHLA CLASS-Ien_US
dc.subjectMarrow Transplantationen_US
dc.subjectAssociationen_US
dc.subjectDonoren_US
dc.subjectRisken_US
dc.titleThe Influence of Human Leukocyte Antigens in Graft Versus Host Disease and Survival After Hematopoietic Stem Cell Transplantation in Pediatric Patients with Leukemiaen_US
dc.typearticleen_US
dc.contributor.departmentİstinye Üniversitesi, Rektörlük, AR-GEen_US
dc.contributor.institutionauthorCarin, Mahmut Nezih
dc.identifier.volume17en_US
dc.identifier.issue4en_US
dc.identifier.startpage280en_US
dc.identifier.endpage285en_US
dc.relation.journalMEDICAL JOURNAL OF BAKIRKOYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000735123100001en_US


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