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Laurus nobilis L. Essential Oil-Loaded PLGA as a Nanoformulation Candidate for Cancer Treatment

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Date

2022

Author

Ercin, E.
Kecel-Gunduz, S.
Gok, B.
Aydin, T.
Budama-Kilinc, Y.
Kartal, M.

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Citation

Ercin, E., Kecel-Gunduz, S., Gok, B., Aydin, T., Budama-Kilinc, Y., & Kartal, M. (2022). Laurus nobilis L. Essential Oil-Loaded PLGA as a Nanoformulation Candidate for Cancer Treatment. Molecules, 27(6), 1899.

Abstract

The aim of this study was to obtain essential oil (LNEO) from the Laurus nobilis L. plant, and to prepare LNEO-loaded poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) as an approach in cancer treatment. The components of the obtained LNEO were analyzed using GC-MS. The LNEO-NPs were synthesized by the single-emulsion method. The LNEO-NPs were charac-terized using UV-Vis spectrometry, Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), and a DNA binding assay, which was performed via the UV-Vis titration method. According to the results, the LNEO-NPs had a 211.4 ± 4.031 nm average particle size, 0.068 ± 0.016 PdI, and −7.87 ± 1.15 mV zeta potential. The encapsulation efficiency and loading capacity were calculated as 59.25% and 25.65%, respectively, and the in vitro drug release study showed an LNEO release of 93.97 ± 3.78% over the 72 h period. Moreover, the LNEO was intercalatively bound to CT-DNA. In addition, the mechanism of action of LNEO on a dual PI3K/mTOR inhibitor was predicted, and its antiproliferative activity and mechanism were determined using molecular docking analysis. It was concluded that LNEO-loaded PLGA NPs may be used for cancer treatment as a novel phytotherapeutic agent-based controlled-release system. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Source

Molecules

Volume

27

Issue

6

URI

https://doi.org/10.3390/molecules27061899
https://hdl.handle.net/20.500.12713/2599

Collections

  • Makale Koleksiyonu [47]
  • PubMed İndeksli Yayınlar Koleksiyonu [994]
  • Scopus İndeksli Yayınlar Koleksiyonu [1549]
  • WoS İndeksli Yayınlar Koleksiyonu [1616]



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