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dc.contributor.authorToplan, Gizem Gulsoy
dc.contributor.authorTaskın, Turgut
dc.contributor.authorIscan, Gokalp
dc.contributor.authorGoger, Fatih
dc.contributor.authorKurkçuoglu, Mine
dc.contributor.authorCivas, Ayşe
dc.contributor.authorEcevit-Genc, Gulay
dc.contributor.authorMat, Afife
dc.contributor.authorBaser, Kemal Husnu Can
dc.date.accessioned2022-04-06T05:46:36Z
dc.date.available2022-04-06T05:46:36Z
dc.date.issued2022en_US
dc.identifier.citationToplan, G. G., Taşkın, T., İşcan, G., Göger, F., Kürkçüoğlu, M., Civaş, A., ... & Başer, K. H. C. (2022). Comparative Studies on Essential Oil and Phenolic Content with In Vitro Antioxidant, Anticholinesterase, Antimicrobial Activities of Achillea biebersteinii Afan. and A. millefolium subsp. millefolium Afan. L. Growing in Eastern Turkey. Molecules, 27(6), 1956.en_US
dc.identifier.urihttps://doi.org/10.3390/molecules27061956.
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2617
dc.description.abstractThe potential applications of Achillea species in various industries have encouraged the examination of their phytochemical components along with their biological potential. In the present study, phenolic contents and essential oil compositions together with the in vitro biological activities of the aerial parts from Achillea biebersteinii Afan. and Achillea millefolium subsp. millefolium Afan. collected from Turkey were evaluated. Different solvent extracts (n-hexane, chloroform, methanol, water) were prepared and their antimicrobial, anticholinesterase, and antioxidant activities were studied. The LC-MS/MS results revealed the presence of 16 different phenolic compounds, including chlorogenic acid, rutin, quercetin, and luteolin glycosides, in methanolic extracts. According to GC-FID and GC/MS results, the primary components of the oils were identified as 1,8-cineole (32.5%), piperitone (14.4%), and camphor (13.7%) in A. biebersteinii and 1,8-cineole (12.3%) and β-eudesmol (8.9%) in A. millefolium subsp. millefolium. The infusion and methanolic extracts of both species were found to be rich in their total phenolic content as well as their antioxidant and anticholinesterase activity. In contrast, the n-hexane and chloroform extracts of both species showed strong antimicrobial activity with MIC values ranging from 15 to 2000 μg/mL. Our findings suggest that the investigated Achillea species could be evaluated as potent natural agents, and further studies into the promising extracts are needed.en_US
dc.language.isoengen_US
dc.relation.isversionof10.3390/molecules27061956en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAchillea Biebersteiniien_US
dc.subjectAchillea Millefolium Subsp. Millefoliumen_US
dc.subjectGC-GC/MSen_US
dc.subjectLC-MS/MSen_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntimicrobialen_US
dc.subjectAntioxidanten_US
dc.subjectEssential Oilen_US
dc.titleComparative Studies on Essential Oil and Phenolic Content with In Vitro Antioxidant, Anticholinesterase, Antimicrobial Activities of Achillea biebersteinii Afan. and A. millefolium subsp. millefolium Afan. L. Growing in Eastern Turkeyen_US
dc.typearticleen_US
dc.contributor.departmentİstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümüen_US
dc.contributor.institutionauthorToplan, Gizem Gulsoy
dc.identifier.volume6en_US
dc.relation.journalMoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.pubmedpublicationid35335326en_US


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