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dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorZarrabi, Ali
dc.contributor.authorMostafavi, Ebrahim
dc.contributor.authorAref, Amir Reza
dc.contributor.authorSethi, Gautam
dc.contributor.authorWang, Lingzhi
dc.contributor.authorTergaonkar, Vinay
dc.date.accessioned2022-06-17T10:28:57Z
dc.date.available2022-06-17T10:28:57Z
dc.date.issued2022en_US
dc.identifier.citationAshrafizadeh M, Zarrabi A, Mostafavi E, Aref AR, Sethi G, Wang L, Tergaonkar V. Non-coding RNA-based regulation of inflammation. Semin Immunol. 2022 Jun 10:101606. doi: 10.1016/j.smim.2022.101606. Epub ahead of print. PMID: 35691882.en_US
dc.identifier.issn1044-5323
dc.identifier.urihttp://doi.org/ 10.1016/j.smim.2022.101606
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2923
dc.description.abstractnflammation is a multifactorial process and various biological mechanisms and pathways participate in its development. The presence of inflammation is involved in pathogenesis of different diseases such as diabetes mellitus, cardiovascular diseases and even, cancer. Non-coding RNAs (ncRNAs) comprise large part of tran- scribed genome and their critical function in physiological and pathological conditions has been confirmed. The present review focuses on miRNAs, lncRNAs and circRNAs as ncRNAs and their potential functions in inflam- mation regulation and resolution. Pro-inflammatory and anti-inflammatory factors are regulated by miRNAs via binding to 3’-UTR or indirectly via affecting other pathways such as SIRT1 and NF-κB. LncRNAs display a similar function and they can also affect miRNAs via sponging in regulating levels of cytokines. CircRNAs mainly affect miRNAs and reduce their expression in regulating cytokine levels. Notably, exosomal ncRNAs have shown ca- pacity in inflammation resolution. In addition to pre-clinical studies, clinical trials have examined role of ncRNAs in inflammation-mediated disease pathogenesis and cytokine regulation. The therapeutic targeting of ncRNAs using drugs and nucleic acids have been analyzed to reduce inflammation in disease therapy. Therefore, ncRNAsen_US
dc.language.isoengen_US
dc.publisherElsevier Scienceen_US
dc.relation.isversionof10.1016/j.smim.2022.101606en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNcRNAsen_US
dc.subjectInflammatory Stormen_US
dc.subjectNF-κBen_US
dc.subjectAnti-inflammatory Mechanismen_US
dc.titleNon-coding RNA-based regulation of inflammationen_US
dc.typearticleen_US
dc.contributor.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.contributor.authorID0000-0003-0391-1769en_US
dc.contributor.institutionauthorZarrabi, Ali
dc.relation.journalSeminars in Imminologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.contributor.wosauthoridU-2602-2019en_US
dc.description.pubmedpublicationid35691882en_US


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