The effect of thiol functional groups on bovine serum albumin/chitosan buccal mucoadhesive patches
Citation
Bal-Öztürk, A., Torkay, G., Alarçin, E., Özbaş, Z., & Özkahraman, B. (2022). The effect of thiol functional groups on bovine serum albumin/chitosan buccal mucoadhesive patches. Journal of Drug Delivery Science and Technology, 74 doi:10.1016/j.jddst.2022.103493Abstract
In this research, the effect of thiol functional groups on bovine serum albumin (BSA)/chitosan (Chi) based buccal
mucoadhesive patch was investigated. Thiolated BSA (BSA-SH) was prepared via 2-mercaptoethanol. FTIR and
1H NMR results confirmed that BSA-SH was synthesized successfully. The buccal mucoadhesive patches were
fabricated by the solvent casting method. Following the structural characterization of BSA/Chi and BSA-SH/Chi
buccal patches, the mechanical characterization was performed by tensile tests. The drug release from triam-
cinolone acetonide (TR) loaded buccal patches was evaluated in-vitro in simulated salivary. According to the ex-
vivo buccal adhesion experiments, the mechanical and mucoadhesion properties of BSA-SH/Chi buccal patch had
improved compared to BSA/Chi buccal patch. The total cumulative TR permeated after 12 h was higher for BSA-
SH/Chi than BSA/Chi buccal patches. The developed mucoadhesive buccal patches were found to be biocom-
patible in vitro. To conclude, the thiolated BSA-SH/Chi buccal adhesive patch is a promising biomaterial for a
satisfied drug delivery, which provides advantages for various oral applications.